Open Access Articles- Top Results for Fetal circulation

Fetal circulation

Fetal circulation
The fetal circulatory system includes three shunts to divert blood from undeveloped and partially functioning organs, as well as blood supply to and from the placenta.
TA Lua error in Module:Wikidata at line 277: attempt to index field 'wikibase' (a nil value).
TH Template:Str mid/core.html {{#property:P1694}}
TE {{#property:P1693}}
FMA Template:FMA
Anatomical terminology

The fetal circulation is the circulatory system of a human fetus, often encompassing the entire fetoplacental circulation which includes the umbilical cord and the blood vessels within the placenta that carry fetal blood.

The fetal circulation works differently from that of born humans, mainly because the lungs are not in use. Instead, the fetus obtains oxygen and nutrients from the mother through the placenta and the umbilical cord.[1]

Placental role

The core concept behind fetal circulation is that fetal hemoglobin (HbF)[2] has a higher affinity for oxygen than does adult hemoglobin, which allows a diffusion of oxygen from the mother's circulatory system to the fetus. The circulatory system of the mother is not directly connected to that of the fetus, so the placenta functions as the respiratory center for the fetus as well as a site of filtration for plasma nutrients and wastes. Water, glucose, amino acids, vitamins, and inorganic salts freely diffuse across the placenta along with oxygen. The umbilical arteries carry blood to the placenta, and the blood permeates the sponge-like material there. Oxygen then diffuses from the placenta to the chorionic villus, an alveolus-like structure, where it is then carried to the umbilical vein.


Blood from the placenta is carried to the fetus by the umbilical vein. Less than a third of this enters the fetal ductus venosus and is carried to the inferior vena cava,[3] while the rest enters the liver proper from the inferior border of the liver. The branch of the umbilical vein that supplies the right lobe of the liver first joins with the portal vein. The blood then moves to the right atrium of the heart. In the fetus, there is an opening between the right and left atrium (the foramen ovale), and most of the blood flows through this hole directly into the left atrium from the right atrium, thus bypassing pulmonary circulation. The continuation of this blood flow is into the left ventricle, and from there it is pumped through the aorta into the body. Some of the blood moves from the aorta through the internal iliac arteries to the umbilical arteries, and re-enters the placenta, where carbon dioxide and other waste products from the fetus are taken up and enter the maternal circulation.[1]

Some of the blood entering the right atrium does not pass directly to the left atrium through the foramen ovale, but enters the right ventricle and is pumped into the pulmonary artery. In the fetus, there is a special connection between the pulmonary artery and the aorta, called the ductus arteriosus, which directs most of this blood away from the lungs (which are not being used for respiration at this point as the fetus is suspended in amniotic fluid).[1]

Blood pressure

It is the fetal heart and not the mother's heart that builds up the fetal blood pressure to drive its blood through the fetal circulation.

Intracardiac pressure remains identical between the right and left ventricles of the human fetus.[4]

The blood pressure in the fetal aorta is approximately 30 mmHg at 20 weeks of gestation, and increases to ca 45 mmHg at 40 weeks of gestation.[5] The fetal pulse pressure is ca 20 mmHg at 20 weeks of gestation, increasing to ca 30 mmHg at 40 weeks of gestation.[5]

The blood pressure decreases when passing through the placenta. In the arteria umbilicalis, it is ca 50 mmHg. It falls to 30 mmHg in the capillaries in the villi. Subsequently, the pressure is 20 mm Hg in the umbilical vein, returning to the heart.[6]


The blood flow through the umbilical cord is approximately 35 mL/min at 20 weeks, and 240 mL/min at 40 weeks of gestation.[7] Adapted to the weight of the fetus, this corresponds to 115 mL/min/kg at 20 weeks and 64 mL/min/kg at 40 weeks.[7] It corresponds to 17% of the combined cardiac output of the fetus at 10 weeks, and 33% at 20 weeks of gestation.[7]

Endothelin and prostanoids cause vasoconstriction in placental arteries, while nitric oxide causes vasodilation.[7] On the other hand, there is no neural vascular regulation, and catecholamines have only little effect.[7]


Further information: Prenatal heartbeat
File:8w3d with umbilical cord.gif
The dynamics of the fetal circulation can be visualized by obstetric ultrasonography, such as on this embryo of 8 weeks.

The fetal heart rate can be monitored by cardiotocography, which includes registering heart contractions by doppler ultrasonography. Also, obstetric ultrasonography using doppler technique on key vessels such as the umbilical artery can detect abnormal flow.

At birth

At birth, when the infant breathes for the first time, there is a decrease in the resistance in the pulmonary vasculature, which causes the pressure in the left atrium to increase relative to the pressure in the right atrium. This leads to the closure of the foramen ovale, which is then referred to as the fossa ovalis. Additionally, the increase in the concentration of oxygen in the blood leads to a decrease in prostaglandins, causing closure of the ductus arteriosus. These closures prevent blood from bypassing pulmonary circulation, and therefore allow the neonate's blood to become oxygenated in the newly operational lungs.[8]

See also

Persistent fetal circulation

Additional images


  1. ^ a b c Whitaker, Kent (2001). "Fetal Circulation". Comprehensive Perinatal and Pediatric Respiratory Care. Delmar Thomson Learning. pp. 18–20. ISBN 978-0-7668-1373-1. 
  2. ^ Edoh, Dominic; Antwi-Bosaiko, Charles; Amuzu, Dominic (March 2006). "Fetal hemoglobin during infancy and in sickle cell adults". African Health Sciences 6 (1): 51–54. PMC 1831961. Retrieved 28 April 2015. 
  3. ^ Kiserud, T.; Rasmussen, S.; Skulstad, S. (2000). "Blood flow and the degree of shunting through the ductus venosus in the human fetus". American journal of obstetrics and gynecology 182 (1 Pt 1): 147–153. PMID 10649170. doi:10.1016/S0002-9378(00)70504-7.  edit
  4. ^ Johnson, P.; D.J., Maxwell, M.J. Tynan, L.D. Allan (2000). "Dr.". Heart 84 (1): 59–63. doi:10.1136/heart.84.1.59. Retrieved 09/04/12.  Check date values in: |accessdate= (help)
  5. ^ a b Struijk, P. C.; Mathews, V. J.; Loupas, T.; Stewart, P. A.; Clark, E. B.; Steegers, E. A. P.; Wladimiroff, J. W. (2008). "Blood pressure estimation in the human fetal descending aorta". Ultrasound in Obstetrics and Gynecology 32 (5): 673–81. PMID 18816497. doi:10.1002/uog.6137. 
  6. ^ "Fetal and maternal blood circulation systems". Swiss Virtual Campus. Retrieved June 29, 2011. 
  7. ^ a b c d e Kiserud, Torvid; Acharya, Ganesh (2004). "The fetal circulation". Prenatal Diagnosis 24 (13): 1049–59. PMID 15614842. doi:10.1002/pd.1062. 
  8. ^ Le, Tao; Bhushan, Vikas; Vasan, Neil (2010). First Aid for the USMLE Step 1: 2010 20th Anniversary Edition. USA: McGraw-Hill. p. 123. ISBN 978-0-07-163340-6.