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Fibrin glue

File:Glued IOL Fig 9.jpg
Fibrin glue applied after drying the scleral bed in an intraocular lens operation

Fibrin glue (also called fibrin sealant) is a formulation used to create a fibrin clot.[1][2][3][4][5][6][7]


It is made up of fibrinogen (lyophilised pooled human concentrate) and thrombin (bovine, which is reconstituted with calcium chloride)[1] that are applied to the tissue sites to glue them together.[1] Thrombin is an enzyme and converts fibrinogen into fibrin monomers between 10 and 60 seconds giving rise to a three-dimensional gel.[6][8]

Factors affecting structure

Factors that influence dimensional structure of fibrin gel giving rise to fine or coarse gel

  1. Changing concentration of fibrinogen
  2. Changing concentration of thrombine- increase concentration increases ultimate tensile strength and youngs modulus of gel
  3. Changing concentration of calcium
  4. pH
  5. Temperature

It may also contain aprotinin, fibronectin and plasminogen.[9] This glue can be used for repairing dura tears, bronchial fistulas and for achieving hemostasis after spleen and liver trauma.[6] It is also employed in "no sutures" corneal transplantation, pterygium excision with amniotic membrane or conjunctival autograft, and in ocular trauma for corneal or conjunctival defects.[10][11] [12]


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