Fibrosis - Related Links
Open Access Articles- Top Results for Fibrosis
Journal of Cell Signaling
A Better Understanding of the Role of TGF-ò Family Members in Tissue FibrosisJournal of Traditional Medicine & Clinical Naturopathy
Role of Natural Marine Products in the Treatment of Hepatic Stellate Cell- Related Liver FibrosisJournal of Anesthesia & Clinical Research
Lung Isolation in a Patient with Sub Mucosal Fibrosis: Anaesthesiologist PerspectiveSurgery: Current Research
Joint Involvement in OchronosisReproductive System & Sexual Disorders: Current Research
Fertility and Reproductive Health Implications of Targeted Therapeutics for Cystic FibrosisFibrosis
| Fibrosis | |
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File:Cardiac amyloidosis very high mag movat.jpg Micrograph of a heart showing fibrosis (yellow - left of image) and amyloid deposition (brown - right of image). Movat's stain. | |
| Classification and external resources | |
| NCI | Fibrosis |
| Patient UK | Fibrosis |
| MeSH | D005355 |
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.[1] This can be a reactive, benign, or pathological state. In response to injury this is called scarring and if fibrosis arises from a single cell line this is called a fibroma. Physiologically this acts to deposit connective tissue, which can obliterate the architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing.[2]
Physiology
Fibrosis is similar to the process of scarring, in that both involve stimulated cells laying down connective tissue, including collagen and glycosaminoglycans. Immune cells called macrophages, as well as any damaged tissue between surfaces called interstitium, release TGF beta. This can be because of numerous reasons, including inflammation of the nearby tissue, or a generalised inflammatory state, with increased circulating mediators. TGF beta stimulates the proliferation and activation of fibroblasts, which deposit connective tissue.[3]
Examples of fibrosis
Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:
Lungs
- Pulmonary fibrosis
- Idiopathic pulmonary fibrosis (idiopathic meaning the cause is unknown)
- Cystic fibrosis
Liver
Heart
Other
- Mediastinal fibrosis (soft tissue of the mediastinum)
- Myelofibrosis (bone marrow)
- Retroperitoneal fibrosis (soft tissue of the retroperitoneum)
- Progressive massive fibrosis (lungs); a complication of coal workers' pneumoconiosis
- Nephrogenic systemic fibrosis (skin)
- Crohn's Disease (intestine)
- Keloid (skin)
- Scleroderma/systemic sclerosis (skin, lungs)
- Arthrofibrosis (knee, shoulder, other joints)
- Peyronie's disease (penis)
- Dupuytren's contracture (hands,fingers)
- Some forms of adhesive capsulitis (shoulder)
References
- ^ Birbrair, A.; Zhang, T.; Wang, Z.-M.; Messi, M. L.; Mintz, A.; Delbono, O. (2013). "Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle". AJP: Cell Physiology 305 (11): C1098. doi:10.1152/ajpcell.00171.2013.
- ^ Glossary of dermatopathological terms. DermNet NZ
- ^ Trojanowska, Maria (15 June 2012). "Mediators of Fibrosis". The Open Rheumatology Journal 6 (1): 70–71. PMC 3395879. PMID 22802903. doi:10.2174/1874312901206010070.
External links
- International Scar Meeting in Tokyo 2010 International Scar Meeting[dead link]
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