Open Access Articles- Top Results for Flufenamic acid

Flufenamic acid

Flufenamic acid
File:Flufenamic acid.png
File:Flufenamic acid-3D-balls.png
Systematic (IUPAC) name
2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid
Clinical data
AHFS/ International Drug Names
oral, topical
Pharmacokinetic data
Protein binding extensively
Metabolism Hydroxylation, glucuronidation
Half-life ~3 h
Excretion 50% urine, 36% feces
530-78-9 7pxY
PubChem CID 3371
IUPHAR ligand 2447
DrugBank DB02266 7pxY
ChemSpider 3254 7pxY
KEGG D01581 7pxY
ChEBI CHEBI:42638 7pxY
Chemical data
Formula C14H10F3NO2
281.22991 g/mol
Physical data
Melting point Script error: No such module "convert". resolidification and remelting at 134°C to 136°C
Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)
 14pxY (what is this?)  (verify)

Flufenamic acid, also known as Fluffy or Fluf[citation needed], is a non-steroidal anti-inflammatory drug.[1] It is pale yellow crystalline powder. In humans, flufenamic acid acts in part by binding to and reducing the activity of prostaglandin F synthase and activating TRPC6, a property it shares with the anti-inflammatory herb St Johns Wort.

Flufenamic acid also blocks voltage-gated sodium channels responsible for the depolarising after-potential (DAP) that underlies phasic firing in the phasic firing of magnocellular neurons in the supraoptic and paraventricular nuclei.[citation needed]


  1. ^ Lovering, A. L.; Ride, J. P.; Bunce, C. M.; Desmond, J. C.; Cummings, S. M.; White, S. A. (2004). "Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin". Cancer research 64 (5): 1802–1810. PMID 14996743.  edit

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