Open Access Articles- Top Results for Fluocinolone acetonide

Fluocinolone acetonide

Fluocinolone acetonide
File:Fluocinolone acetonide.svg
File:Fluocinolone acetonide (Ball-n-Stick).png
Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
  • C
  • Prescription Only
Pharmacokinetic data
Metabolism Hepatic, CYP3A4-mediated
Half-life 1.3 to 1.7 hours
67-73-2 7pxY
C05AA10 D07AC04 S01BA15 S02BA08
PubChem CID 6215
DrugBank DB00591 7pxY
ChemSpider 5980 7pxY
KEGG D01825 7pxY
ChEBI CHEBI:31623 7pxN
Chemical data
Formula C24H30F2O6
452.488 g/mol
 14pxN (what is this?)  (verify)

Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. It was first synthesized in 1959 in the Research Department of Syntex Laboratories S.A. Mexico City.[1] Preparations containing it were first marketed under the name Synalar. A typical dosage strength used in dermatology is 0.01–0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin.

Fluocinolone acetonide was also found to strongly potentiate TGF-β-associated chondrogenesis of bone marrow mesenchymal stem/progenitor cells, by increasing the levels of collagen type II by more than 100 fold compared to the widely used dexamethasone.[2]

Flucinolone is a group IV (0.01-0.2%) or group V (0.025%) corticosteroid under US classification.

See also


  1. ^ J S Mills, A. Bowers, Carl Djerassi and H.J. Ringold, Steroids CXXXVII. Synthesis of a New Class of Potent Cortical Hormones. 6α,9α-Difluoro-16α-Hydroxyprednisolone and its Acetonide, Journal of the American Chemical Society, 80, 3399-3404 (1960)
  2. ^ Hara ES, Ono M, Pham HT, Sonoyama W, Kubota S, Takigawa M, Matsumoto T, Young MF, Olsen BR, Kuboki T. Fluocinolone Acetonide is a Potent Synergistic Factor of TGF-β3-Associated Chondrogenesis of Bone Marrow-Derived Mesenchymal Stem Cells for Articular Surface Regeneration. J Bone Miner Res. 2015.

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