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Open Access Articles- Top Results for Fluralaner

Fluralaner

Fluralaner
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IUPAC name
4-[(5R/S)-5-(3,5-Dichlorophenyl)-4,5-dihydro-5-trifluoromethyl-1,2-oxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-o-toluamide
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ATCvet code QP53BX05
864731-61-3 (A)
ChemSpider 29398949 7pxY
Jmol-3D images Image
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C22H17Cl2F6N3O3
Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Fluralaner is an insecticide. The US Food and Drug Administration (FDA) approved the product Bravecto for flea treatment in dogs in May 2014.[1] The EU approved the drug in February 2014.[2]

Mode of action

Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABACls) and l-glutamate-gated chloride channels (GluCls).[3]

References

  1. ^ Lee, Justin (21 May 2014). "New flea/tick medication by Merck just approved: Bravecto". Retrieved 3 Nov 2014. 
  2. ^ "MSD Animal Health receives EU approval for Bravecto". 19 Feb 2014. Retrieved 3 Nov 2014. 
  3. ^ Gassel1, Michael; Wolf, Christian; Noack, Sandra; Williams, Heike; Ilg, Thomas (February 2014). "The novel isoxazoline ectoparasiticide fluralaner: Selective inhibition of arthropod γ-aminobutyric acid- and l-glutamate-gated chloride channels and insecticidal/acaricidal activity". Insect Biochemistry and Molecular Biology 45: 111–124. doi:10.1016/j.ibmb.2013.11.009.