Open Access Articles- Top Results for Fyn-related kinase

Fyn-related kinase

SymbolsFRK ; GTK; PTK5; RAK
External IDsOMIM606573 MGI103265 HomoloGene48065 IUPHAR: 2025 ChEMBL: 4223 GeneCards: FRK Gene
EC number2.7.10.2
RNA expression pattern
File:PBB GE FRK 207178 s at tn.png
More reference expression data
RefSeq (mRNA)NM_002031NM_001159544
RefSeq (protein)NP_002022NP_001153016
Location (UCSC)Chr 6:
116.25 – 116.38 Mb
Chr 10:
34.48 – 34.61 Mb
PubMed search[1][2]

Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[1][2]

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[2]


FRK has been shown to interact with retinoblastoma protein.[3]


  1. ^ Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene 138 (1-2): 247–51. PMID 7510261. doi:10.1016/0378-1119(94)90817-6. 
  2. ^ a b "Entrez Gene: FRK fyn-related kinase". 
  3. ^ Craven, R J; Cance W G; Liu E T (September 1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb". Cancer Res. (UNITED STATES) 55 (18): 3969–72. ISSN 0008-5472. PMID 7664264. 

Further reading


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