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Open Access Articles- Top Results for GBR-13098

GBR-13098

GBR-13098
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IUPAC name
1-{2-[Bis(4-fluorophenyl)methoxy]ethyl}-4-[3-(4-fluorophenyl)propyl]piperazine
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ChemSpider 117130
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C28H31F3N2O
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.[1]

Blocking the endogenous striatal dopamine (DA) transporter with GBR-13098 in mice has been shown to prevented damage to the DA nerve terminals caused by malonate. It was suggested that DA transpoter inhibitors like GBR-13098 could be used to prevent or treat neruodegenerative disorders caused by the effect of mitochondrial dysfunction on DA homeostasis.[2]

See also

References

  1. ^ Pileblad E, and Engberg G. (Dec 1986). "GBR 13098, a selective dopamine uptake inhibitor; behavioural, biochemical and electrophysiological studies.". Naunyn Schmiedebergs Arch Pharmacol. 334 (4): 383–7. PMID 2950328. 
  2. ^ Moy LY et al. (Feb 2007). "Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.". J Pharmacol Exp Ther. 320 (2): 747–56. doi:10.1124/jpet.106.110791. 



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