Adverts

Open Access Articles- Top Results for GJB5

GJB5

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsGJB5 ; CX31.1
External IDsOMIM604493 MGI95723 HomoloGene3858 IUPHAR: 721 GeneCards: GJB5 Gene
Orthologs
SpeciesHumanMouse
Entrez270914622
EnsemblENSG00000189280ENSMUSG00000042357
UniProtO95377Q02739
RefSeq (mRNA)NM_005268NM_010291
RefSeq (protein)NP_005259NP_034421
Location (UCSC)Chr 1:
35.22 – 35.22 Mb
Chr 4:
127.35 – 127.36 Mb
PubMed search[1][2]

Gap junction beta-5 protein (GJB5), also known as connexin-31.1 (Cx31.1), is a protein that in humans is encoded by the GJB5 gene.[1]

Function

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family.[1]

References

Further reading

  • Canova C, Hashibe M, Simonato L et al. (2009). "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.". Cancer Res. 69 (7): 2956–65. PMID 19339270. doi:10.1158/0008-5472.CAN-08-2604. 
  • Richard G, Smith LE, Bailey RA et al. (1998). "Mutations in the human connexin gene GJB3 cause erythrokeratodermia variabilis.". Nat. Genet. 20 (4): 366–9. PMID 9843209. doi:10.1038/3840. 
</dl>

Lua error in package.lua at line 80: module 'Module:Buffer' not found. This article incorporates text from the United States National Library of Medicine, which is in the public domain.