Open Access Articles- Top Results for GPR101


SymbolsGPR101 ; GPCR6
External IDsOMIM300393 MGI2685211 HomoloGene14273 IUPHAR: 125 GeneCards: GPR101 Gene
RNA expression pattern
File:PBB GE GPR101 gnf1h01265 at tn.png
More reference expression data
RefSeq (mRNA)NM_054021NM_001033360
RefSeq (protein)NP_473362NP_001028532
Location (UCSC)Chr X:
137.03 – 137.03 Mb
Chr X:
57.5 – 57.5 Mb
PubMed search[1][2]

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[2]

Clinical significance

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly.[3]


  1. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. PMID 11574155. doi:10.1016/S0378-1119(01)00651-5. 
  2. ^ a b "Entrez Gene: GPR101 G protein-coupled receptor 101". 
  3. ^ Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO et al. (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. PMID 25470569. doi:10.1056/NEJMoa1408028. 

Further reading

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. PMID 12044878. doi:10.1016/S0014-5793(02)02775-8. 

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