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Open Access Articles- Top Results for GPR114

GPR114

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Identifiers
SymbolsGPR114 ; PGR27
External IDsMGI2685955 HomoloGene17828 IUPHAR: 194 GeneCards: GPR114 Gene
Orthologs
SpeciesHumanMouse
Entrez221188382045
EnsemblENSG00000159618ENSMUSG00000061577
UniProtQ8IZF4Q3V3Z3
RefSeq (mRNA)NM_153837NM_001033468
RefSeq (protein)NP_722579NP_001028640
Location (UCSC)Chr 16:
57.58 – 57.63 Mb
Chr 8:
94.92 – 94.94 Mb
PubMed search[1][2]

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.[1][2][3] GPR114 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[7]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.[8]

References

  1. ^ "Entrez Gene: GPR114 G protein-coupled receptor 114". 
  2. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. PMID 12435584. doi:10.1016/S0014-5793(02)03574-3. 
  3. ^ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological reviews 67 (2): 338–67. PMID 25713288. 
  4. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 1-4419-7912-3. 
  5. ^ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science signaling 6 (276): re3. PMID 23695165. 
  6. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC et al. (Mar 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. PMC 3321182. PMID 22333914. doi:10.1038/emboj.2012.26. 
  7. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. PMID 25713288. doi:10.1124/pr.114.009647. 
  8. ^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (Apr 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters 586 (8): 1214–9. PMID 22575658. doi:10.1016/j.febslet.2012.03.014. 

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