Open Access Articles- Top Results for GPR143


SymbolsGPR143 ; NYS6; OA1
External IDsOMIM300808 MGI107193 HomoloGene230 IUPHAR: 203 GeneCards: GPR143 Gene
RNA expression pattern
File:PBB GE GPR143 206696 at tn.png
More reference expression data
RefSeq (mRNA)NM_000273NM_010951
RefSeq (protein)NP_000264NP_035081
Location (UCSC)Chr X:
9.69 – 9.75 Mb
Chr X:
152.78 – 152.81 Mb
PubMed search[1][2]
Ocular albinism type 1 protein
Symbol Ocular_alb
Pfam PF02101
Pfam clan CL0192
InterPro IPR001414

G-protein coupled receptor 143 is a protein encoded by the GPR143 gene in humans.[1][2][3]

Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes.[3]

The GPR143 gene is regulated by the Microphthalmia-associated transcription factor.[4][5]

L-DOPA is an endogenous ligand for OA1.[6]


GPR143 has been shown to interact with GNAI1.[2]


  1. ^ Bassi MT, Schiaffino MV, Renieri A, De Nigris F, Galli L, Bruttini M, Gebbia M, Bergen AA, Lewis RA, Ballabio A (Sep 1995). "Cloning of the gene for ocular albinism type 1 from the distal short arm of the X chromosome". Nat Genet 10 (1): 13–9. PMID 7647783. doi:10.1038/ng0595-13. 
  2. ^ a b Schiaffino MV, d'Addio M, Alloni A, Baschirotto C, Valetti C, Cortese K, Puri C, Bassi MT, Colla C, De Luca M, Tacchetti C, Ballabio A (Sep 1999). "Ocular albinism: evidence for a defect in an intracellular signal transduction system". Nat Genet 23 (1): 108–12. PMID 10471510. doi:10.1038/12715. 
  3. ^ a b "Entrez Gene: GPR143 G protein-coupled receptor 143". 
  4. ^ Vetrini F, Auricchio A, Du J et al. (2004). "The microphthalmia transcription factor (Mitf) controls expression of the ocular albinism type 1 gene: link between melanin synthesis and melanosome biogenesis". Mol. Cell. Biol. 24 (15): 6550–9. PMC 444869. PMID 15254223. doi:10.1128/MCB.24.15.6550-6559.2004. 
  5. ^ Hoek KS, Schlegel NC, Eichhoff OM et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x. 
  6. ^ Lopez VM, Decatur CL, Stamer WD, Lynch RM, McKay BS (September 2008). Barsh, Gregory S., ed. "L-DOPA is an endogenous ligand for OA1". PLoS Biol. 6 (9): e236. PMC 2553842. PMID 18828673. doi:10.1371/journal.pbio.0060236. 

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