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Open Access Articles- Top Results for GPR152

GPR152

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Identifiers
SymbolsGPR152 ; PGR5
External IDsMGI2685519 HomoloGene35474 IUPHAR: 138 GeneCards: GPR152 Gene
RNA expression pattern
File:PBB GE GPR152 gnf1h05602 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez390212269053
EnsemblENSG00000175514ENSMUSG00000044724
UniProtQ8TDT2Q8BXS7
RefSeq (mRNA)NM_206997NM_206973
RefSeq (protein)NP_996880NP_996856
Location (UCSC)Chr 11:
67.22 – 67.22 Mb
Chr 19:
4.14 – 4.15 Mb
PubMed search[1][2]

Probable G-protein coupled receptor 152 is a protein that in humans is encoded by the GPR152 gene.[1][2]


Model organisms

Model organisms have been used in the study of GPR152 function. A conditional knockout mouse line called Gpr152tm1b(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]



References

  1. ^ Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc Natl Acad Sci U S A 100 (8): 4903–8. PMC 153653. PMID 12679517. doi:10.1073/pnas.0230374100. 
  2. ^ "Entrez Gene: GPR152 G protein-coupled receptor 152". 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. PMC 3572410. PMID 21677750. doi:10.1038/nature10163. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. PMID 23870131. doi:10.1016/j.cell.2013.06.022. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading

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