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Open Access Articles- Top Results for GPR81

GPR81

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Identifiers
SymbolsHCAR1 ; GPR104; GPR81; HCA1; LACR1; TA-GPCR; TAGPCR
External IDsOMIM606923 MGI2441671 HomoloGene13060 IUPHAR: 311 ChEMBL: 1075101 GeneCards: HCAR1 Gene
RNA expression pattern
File:PBB GE GPR81 gnf1h00809 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez27198243270
EnsemblENSG00000196917ENSMUSG00000049241
UniProtQ9BXC0Q8C131
RefSeq (mRNA)NM_032554NM_175520
RefSeq (protein)NP_115943NP_780729
Location (UCSC)Chr 12:
123.1 – 123.22 Mb
Chr 5:
123.88 – 123.88 Mb
PubMed search[1][2]

G protein-coupled receptor 81, also known as GPR81, is a protein that in humans is encoded by the GPR81 gene.[1][2]

G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[1]

Lactate activates the GPR81 receptor which in turn inhibits lipolysis in fat cells.[3][4]

References

  1. ^ a b "Entrez Gene: GPR81 G protein-coupled receptor 81". 
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (September 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. PMID 11574155. doi:10.1016/S0378-1119(01)00651-5. 
  3. ^ Liu C, Wu J, Zhu J, Kuei C, Yu J, Shelton J, Sutton SW, Li X, Yun SJ, Mirzadegan T, Mazur C, Kamme F, Lovenberg TW (January 2009). "Lactate inhibits lipolysis in fat cells through activation of an orphan G-protein-coupled receptor, GPR81". J. Biol. Chem. 284 (5): 2811–22. PMID 19047060. doi:10.1074/jbc.M806409200. 
  4. ^ Cai TQ, Ren N, Jin L, Cheng K, Kash S, Chen R, Wright SD, Taggart AK, Waters MG (December 2008). "Role of GPR81 in lactate-mediated reduction of adipose lipolysis". Biochem. Biophys. Res. Commun. 377 (3): 987–91. PMID 18952058. doi:10.1016/j.bbrc.2008.10.088. 

Further reading

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