Open Access Articles- Top Results for GPRC5A


External IDsOMIM604138 MGI1891250 HomoloGene2961 IUPHAR: 258 GeneCards: GPRC5A Gene
RefSeq (mRNA)NM_003979NM_181444
RefSeq (protein)NP_003970NP_852109
Location (UCSC)Chr 12:
13.04 – 13.07 Mb
Chr 6:
135.07 – 135.08 Mb
PubMed search[1][2]

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene.[1][2]


This gene encodes a member of the type 3 G protein-coupled receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoic acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation.[2]

Post transcriptional regulation

GPRC5A is one of only a handful of genes known in the literature that are post-transcriptionally controlled by miRNAs through their 5'UTR.[3]

Clinical Significance

GPRC5A is dysregulated in many human cancers and in other diseases.[4]

See also


  1. Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. PMID 9857033. doi:10.1074/jbc.273.52.35008. 
  2. 2.0 2.1 "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A". 
  3. Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets the 5' UTR of GPRC5A in pancreatic cells". RNA 20 (9): 1431–9. PMC 4138326. PMID 24984703. doi:10.1261/rna.045757.114. 
  4. Zhou H, Rigoutsos I (2014). "The emerging roles of GPRC5A in diseases". Oncoscience 1 (12): 765–76. PMC 4303886. PMID 25621293. 

Further reading

  • Cafferata EG, Gonzalez-Guerrico AM, Pivetta OH, Santa-Coloma TA (1996). "Identification by differential display of a mRNA specifically induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in T84 human colon carcinoma cells". Cell. Mol. Biol. (Noisy-le-grand) 42 (5): 797–804. PMID 8832110. 
  • Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics 65 (2): 121–8. PMID 10783259. doi:10.1006/geno.2000.6164. 
  • Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I et al. (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics 67 (1): 8–18. PMID 10945465. doi:10.1006/geno.2000.6226. 
  • Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its regulation by retinoic acid". Genomics 83 (2): 270–80. PMID 14706456. doi:10.1016/S0888-7543(03)00237-4. 
  • Wu Q, Ding W, Mirza A, Van Arsdale T, Wei I, Bishop WR et al. (2005). "Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target". J. Biol. Chem. 280 (13): 12935–43. PMID 15659406. doi:10.1074/jbc.M409901200. 
  • Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell Proteomics 4 (9): 1240–50. PMID 15951569. doi:10.1074/mcp.M500089-MCP200. 
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. PMC 1459365. PMID 16565220. doi:10.1073/pnas.0507066103. 
  • Hirano M, Zang L, Oka T, Ito Y, Shimada Y, Nishimura Y et al. (2006). "Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression". Biochem. Biophys. Res. Commun. 351 (1): 185–91. PMID 17055459. doi:10.1016/j.bbrc.2006.10.016. 

External links

  • "GPRC5 Receptors: RAIG1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

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