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Open Access Articles- Top Results for GRK4

GRK4

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Identifiers
SymbolsGRK4 ; GPRK2L; GPRK4; GRK4a; IT11
External IDsOMIM137026 MGI95801 HomoloGene23158 IUPHAR: 1468 ChEMBL: 5861 GeneCards: GRK4 Gene
EC number2.7.11.16
RNA expression pattern
File:PBB GE GRK4 208365 s at tn.png
File:PBB GE GRK4 210600 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez286814772
EnsemblENSG00000125388ENSMUSG00000052783
UniProtP32298O70291
RefSeq (mRNA)NM_001004056NM_001080743
RefSeq (protein)NP_001004056NP_001074212
Location (UCSC)Chr 4:
2.97 – 3.04 Mb
Chr 5:
34.66 – 34.76 Mb
PubMed search[1][2]

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.[1][2]

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension.[2]

References

  1. ^ Ambrose C, James M, Barnes G, Lin C, Bates G, Altherr M, Duyao M, Groot N, Church D, Wasmuth JJ et al. (Jun 1993). "A novel G protein-coupled receptor kinase gene cloned from 4p16.3". Hum Mol Genet 1 (9): 697–703. PMID 1338872. doi:10.1093/hmg/1.9.697. 
  2. ^ a b "Entrez Gene: GRK4 G protein-coupled receptor kinase 4". 

Further reading

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