Open Access Articles- Top Results for Galanin receptor 3

Galanin receptor 3

External IDsOMIM603692 MGI1329003 HomoloGene20798 IUPHAR: 245 ChEMBL: 2731 GeneCards: GALR3 Gene
RNA expression pattern
File:PBB GE GALR3 33579 i at tn.png
More reference expression data
RefSeq (mRNA)NM_003614NM_015738
RefSeq (protein)NP_003605NP_056553
Location (UCSC)Chr 22:
38.22 – 38.22 Mb
Chr 15:
79.03 – 79.04 Mb
PubMed search[1][2]

Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[1]

The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[1]

See also


External links

  • "Galanin Receptors: GAL3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

  • Smith KE, Walker MW, Artymyshyn R et al. (1998). "Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels". J. Biol. Chem. 273 (36): 23321–6. PMID 9722565. doi:10.1074/jbc.273.36.23321. 
  • Kolakowski LF, O'Neill GP, Howard AD et al. (1998). "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3". J. Neurochem. 71 (6): 2239–51. PMID 9832121. doi:10.1046/j.1471-4159.1998.71062239.x. 
  • Iismaa TP, Fathi Z, Hort YJ et al. (1999). "Structural organization and chromosomal localization of three human galanin receptor genes". Ann. N. Y. Acad. Sci. 863: 56–63. PMID 9928159. doi:10.1111/j.1749-6632.1998.tb10683.x. 
  • Lapsys NM, Furler SM, Henderson NK et al. (1999). "A polymorphism in the human GALR3 galanin receptor gene (GALNR3)". Mol. Cell. Probes 13 (4): 325–7. PMID 10441207. doi:10.1006/mcpr.1999.0254. 
  • Dunham I, Shimizu N, Roe BA et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. PMID 10591208. doi:10.1038/990031. 
  • Berger A, Tuechler C, Almer D et al. (2002). "Elevated expression of galanin receptors in childhood neuroblastic tumors". Neuroendocrinology 75 (2): 130–8. PMID 11867941. doi:10.1159/000048229. 
  • Belfer I, Hipp H, Bollettino A et al. (2007). "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior 6 (5): 473–81. PMID 17083333. doi:10.1111/j.1601-183X.2006.00275.x. 
  • Runesson J, Sollenberg UE, Jurkowski W et al. (2010). "Determining receptor–ligand interaction of human galanin receptor type 3". Neurochem. Int. 57 (7): 804–811. PMID 20817064. doi:10.1016/j.neuint.2010.08.018. 

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