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Open Access Articles- Top Results for Galnon

Galnon

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Galnon
200px
Systematic (IUPAC) name
9H-fluoren-9-ylmethyl N-[(2S)-1-([(2S)-6-amino-1-[(4-methyl-2-oxochromen-7- yl)amino]-1-oxohexan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]carbamate
Clinical data
Identifiers
475115-35-6 7pxY
PubChem CID 5311268
ChemSpider 4470781 7pxN
ChEMBL CHEMBL592414 7pxN
Chemical data
Formula C40H46N4O6
678.815
 14pxN (what is this?)  (verify)

Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1][2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.[3][4][5][6][7]

References

  1. Saar K, Mazarati AM, Mahlapuu R, Hallnemo G, Soomets U, Kilk K, Hellberg S, Pooga M, Tolf BR, Shi TS, Hökfelt T, Wasterlain C, Bartfai T, Langel U (May 2002). "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7136–41. PMC 124541. PMID 12011470. doi:10.1073/pnas.102163499. 
  2. Sollenberg U, Bartfai T, Langel U (June 2005). "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides 39 (3): 161–3. PMID 15944006. doi:10.1016/j.npep.2004.12.019. 
  3. Abramov U, Florén A, Echevarria DJ, Brewer A, Manuzon H, Robinson JK, Bartfai T, Vasar E, Langel U (February 2004). "Regulation of feeding by galnon". Neuropeptides 38 (1): 55–61. PMID 15003717. doi:10.1016/j.npep.2004.01.001. 
  4. Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. PMID 15944018. doi:10.1016/j.npep.2004.12.010. 
  5. Rajarao SJ, Platt B, Sukoff SJ, Lin Q, Bender CN, Nieuwenhuijsen BW, Ring RH, Schechter LE, Rosenzweig-Lipson S, Beyer CE (October 2007). "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides 41 (5): 307–20. PMID 17637475. doi:10.1016/j.npep.2007.05.001. 
  6. Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H (March 2009). "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry 65 (5): 383–91. PMID 19095221. doi:10.1016/j.biopsych.2008.10.034. 
  7. Narasimhaiah R, Kamens HM, Picciotto MR (May 2009). "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology 204 (1): 95–102. PMC 2872184. PMID 19099295. doi:10.1007/s00213-008-1438-7. 


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