Open Access Articles- Top Results for Gamete
Human Genetics & EmbryologyClinician-Induced (Iatrogenic) Damage Incurred during Human Fertility Treatment: Detrimental Effects upon Gamete and Embryo Viability and the Potent
Journal of Fertilization: In Vitro - IVF-WorldwideIn Vitro Manipulation of Mammalian Gametes and Embryos: What are we learning from Animal Settings?
A gamete (from Ancient Greek γαμετή gamete "wife") is a cell that fuses with another cell during fertilization (conception) in organisms that sexually reproduce. In species that produce two morphologically distinct types of gametes, and in which each individual produces only one type, a female is any individual that produces the larger type of gamete—called an ovum (or egg)—and a male produces the smaller tadpole-like type—called a sperm. This is an example of anisogamy or heterogamy, the condition in which females and males produce gametes of different sizes (this is the case in humans; the human ovum has approximately 100,000 times the volume of a single human sperm cell). In contrast, isogamy is the state of gametes from both sexes being the same size and shape, and given arbitrary designators for mating type. The name gamete was introduced by the Austrian biologist Gregor Mendel. Gametes carry half the genetic information of an individual, one ploidy of each type, and are created through meiosis.
In contrast to a gamete, the diploid somatic cells of an individual contain one copy of the chromosome set from the sperm and one copy of the chromosome set from the egg cell; that is, the cells of the offspring have genes expressing characteristics of both the father and the mother. A gamete's chromosomes are not exact duplicates of either of the sets of chromosomes carried in the diploid chromosomes, and often undergo random mutations resulting in modified DNA (and subsequently, new proteins and phenotypes).
Plants which reproduce sexually also have gametes. However, since plants have an alternation of diploid and haploid generations some differences exist. In flowering plants the flowers use meiosis to produce a haploid generation which produce gametes through mitosis. The female haploid is called the ovule and is produced by the ovary of the flower. When mature the haploid ovule produces the female gamete which are ready for fertilization. The male haploid is pollen and is produced by the anther, when pollen lands on a mature stigma of a flower it grows a pollen tube down into the flower. The haploid pollen then produces sperm by mitosis and releases them for fertilization.
Sex determination in humans and birds
In humans, a normal ovum can carry only an X chromosome (of the X and Y chromosomes), whereas a sperm may carry either an X or a Y (a non-normal ovum can end up carrying two or no X chromosomes, as a result of a mistake at either of the two stages of meiosis, while a non-normal sperm cell can end up carrying either no sex-defining chromosomes,an XY pair, an XX pair or a YY pair as a result of the forementioned reason); ergo the male sperm determines the sex of any resulting zygote, if the zygote has two X chromosomes it will develop into a female, if it has an X and a Y chromosome, it will develop into a male. For birds, the female ovum determines the sex of the offspring, through the ZW sex-determination system.
Artificial gametes, also known as In vitro derived gametes (IVD), stem cell-derived gametes (SCDGs), and In vitro generated gametes (IVG), are gametes derived from stem cells. Research shows that artificial gametes may be a reproductive technique for same-sex male couples, although a surrogate mother would still be required for the gestation period. Women who have passed menopause may be able to produce eggs and bear genetically related children with artificial gametes. Robert Sparrow wrote, in the Journal of Medical Ethics, that embryos derived from artificial gametes could be used to derive new gametes and this process could be repeated to create multiple human generations in the laboratory. This technique could be used to create cell lines for medical applications and for studying the heredity of genetic disorders. Additionally, this technique could be used for human enhancement by selectively breeding for a desired genome or by using recombinant DNA technology to create enhancements that have not arisen in nature.
Notes and references
- "gamete". Online Etymology Dictionary.
- Marshall, A. M. 1893. Vertebrate embryology: a text-book for students and practitioners. GP Putnam's sons.
- Yeung, C., M. Anapolski, M. Depenbusch, M. Zitzmann, and T. Cooper. 2003. Human sperm volume regulation. Response to physiological changes in osmolality, channel blockers and potential sperm osmolytes. Human Reproduction 18:1029.
- Jay Phelan (30 April 2009). What Is Life?: A Guide to Biology W/Prep-U. Macmillan. pp. 237–. ISBN 978-1-4292-2318-8. Retrieved 8 October 2010.
- Newson, A J; Smajdor, A C (2005). "Artificial gametes: new paths to parenthood?" (PDF). Journal of Medical Ethics 31: 184–186. doi:10.1136/jme.2003.004986. Retrieved February 26, 2015.
- Sparrow, Robert (April 4, 2013). "In vitro eugenics". Journal of Medical Ethics. doi:10.1136/medethics-2012-101200. Retrieved 8 March 2015.