Gene family - Related Links
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A gene family is a set of several similar genes, formed by duplication of a single original gene, and generally with similar biochemical functions. One such family are the genes for human haemoglobin subunits; the ten genes are in two clusters on different chromosomes, called the α-globin and β-globin loci.
Genes are categorized into families based on shared nucleotide or protein sequences. Phylogenetic techniques can be used as a more rigorous test. The positions of exons within the coding sequence can be used to infer common ancestry. Knowing the sequence of the protein encoded by a gene can allow researchers to apply methods that find similarities among protein sequences that provide more information than similarities or differences among DNA sequences. Furthermore, knowledge of the protein's secondary structure gives further information about ancestry, since the organization of secondary structural elements presumably would be conserved even if the amino acid sequence changes considerably. These methods often rely upon predictions based upon the DNA sequence.
If the genes of a gene family encode proteins, the term protein family is often used in an analogous manner to gene family.
The expansion or contraction of gene families along a specific lineage can be due to chance, or can be the result of natural selection. To distinguish between these two cases is often difficult in practice. Recent work uses a combination of statistical models and algorithmic techniques to detect gene families that are under the effect of natural selection.
The HUGO Gene Nomenclature Committee (HGNC) creates nomenclature schemes using a "stem" (or "root") symbol for members of a gene family, with a hierarchical numbering system to distinguish the individual members.
- Hartl, D.L. and Clark A.G. 2007. Principles of population genetics. Chapter 7, page 372.
- The Evolution of Mammalian Gene Families
- Daugherty, LC; Seal, RL; Wright, MW; Bruford, EA (Jul 5, 2012). "Gene family matters: expanding the HGNC resource.". Human genomics 6 (1): 4. PMC 3437568. PMID 23245209. doi:10.1186/1479-7364-6-4.
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