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George Minot

George Minot
File:George Minot nobel.jpg
Born ( 1885-12-02)December 2, 1885
Boston, Massachusetts
Died February 25, 1950(1950-02-25) (aged 64)
Nationality United States
Institutions Johns Hopkins School of Medicine
Alma mater Harvard University
Doctoral advisor Template:If empty
Known for Anemia
Treatment of pernicious anemia
Notable awards 1934 Nobel Prize in Physiology or Medicine

Not to be confused with American historian and judge George Richards Minot (judge) (1758–1802)

George Richards Minot (December 2, 1885 – February 25, 1950) was an American medical researcher who shared the 1934 Nobel Prize with George Hoyt Whipple and William P. Murphy for their pioneering work on pernicious anemia.


George Richards Minot was born in Boston, Massachusetts. He came from a medical family; his father was physician James Jackson Minot (1853–1938).[1] One of his great-grandfathers was James Jackson (1777–1867), co-founder of Massachusetts General Hospital.[2] He was namesake of his great-great-grandfather George Richards Minot (1758–1802).[3] His mother was Elizabeth Whitney. His father's cousin was anatomist Charles Sedgwick Minot (1852–1914).[4]

He completed his A.B. in 1908 and his M.D. in 1912 from Harvard University. Between 1914 to 1915, George Minot was appointed Assistant in Medicine at the Johns Hopkins University in Baltimore, MD. In 1915, he was appointed Assistant in Medicine at the Harvard Medical School. Minot won the 1934 Nobel Prize in Physiology or Medicine with William P. Murphy and George H. Whipple for their work in the study of anemia. George Minot, working with William Murphy, described an effective treatment for pernicious anemia with liver (which is high in vitamin B12, later identified as the critical compound in the treatment.)

Minot had diabetes mellitus, which was a uniformly fatal disease during the early part of his life. Dr. William Castle observed that Banting and Best's 1921 discovery of insulin not only transformed diabetes treatment, but, by keeping Minot alive, was therefore also responsible for the discovery of a cure for pernicious anemia.[5]

Minot began suffering from complications associated with diabetes in 1947, suffering a serious stroke the same year.[6] He died on February 25, 1950.[2] He was a Unitarian.[7] His home in Brookline, Massachusetts, was designated a National Historic Landmark in recognition for his work.[6]

Minot and his wife Marian (1890-1979) had two daughters and a son.


  1. "Obituary". New England Journal of Medicine 242 (14): 565–565. April 6, 1950. doi:10.1056/NEJM195004062421414. 
  2. 2.0 2.1 Robert A. Kyle; Marc A. Shampo (November 2002). "George R. Minot—Nobel Prize for the treatment of pernicious anemia". Mayo Clinic Proceedings (United States) 77 (11): 1150. ISSN 0025-6196. PMID 12440548. doi:10.4065/77.11.1150. 
  3. Winthrop, Robert Charles (March 12, 1874). "Hon, William Minot". Memoir read at a meetingof the Massachusetts Historical Society: 302–306. 
  4. "Sedgwick Family Papers 1717–1946 Guide to the Collection". Massachusetts Historical Society. Retrieved February 4, 2011. 
  5. Castle, W B (1962). "The Gordon Wilson Lecture: A century of curiosity about pernicious anemia". Trans Am Clin Climatol Assoc 73: 54–80. PMC 2249021. PMID 21408623. 
  6. 6.0 6.1 "NHL nomination for George R. Minot House" (PDF). National Park Service. Retrieved 2014-05-20. 
  7. "George R. Minot". Notable Names Database. Retrieved 2011-09-18. 

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