Open Access Articles- Top Results for Germ cell nuclear factor

Germ cell nuclear factor

SymbolsNR6A1 ; CT150; GCNF; GCNF1; NR61; RTR; hGCNF; hRTR
External IDsOMIM602778 MGI1352459 HomoloGene36308 IUPHAR: 634 GeneCards: NR6A1 Gene
RNA expression pattern
File:PBB GE NR6A1 207742 s at tn.png
File:PBB GE NR6A1 210391 at tn.png
File:PBB GE NR6A1 210392 x at tn.png
More reference expression data
RefSeq (mRNA)NM_001278546NM_001159548
RefSeq (protein)NP_001265475NP_001153020
Location (UCSC)Chr 9:
127.28 – 127.53 Mb
Chr 2:
38.72 – 38.93 Mb
PubMed search[1][2]

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a protein that in humans is encoded by the NR6A1 gene.[1][2] GCNF is a member of the nuclear receptor family of intracellular transcription factors .

In adults, GCNH is expressed mainly in the germ cells of gonads and is involved in the regulation of embryogenesis and germ cell differentiation.[3]

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.[4]


  1. ^ Lei W, Hirose T, Zhang LX, Adachi H, Spinella MJ, Dmitrovsky E, Jetten AM (1997). "Cloning of the human orphan receptor germ cell nuclear factor/retinoid receptor-related testis-associated receptor and its differential regulation during embryonal carcinoma cell differentiation". J. Mol. Endocrinol. 18 (2): 167–76. PMID 9134503. doi:10.1677/jme.0.0180167. 
  2. ^ Süsens U, Borgmeyer U (1996). "Characterization of the human germ cell nuclear factor gene". Biochim. Biophys. Acta 1309 (3): 179–82. PMID 8982251. doi:10.1016/s0167-4781(96)00157-1. 
  3. ^ Zechel C (2005). "The germ cell nuclear factor (GCNF)". Mol. Reprod. Dev. 72 (4): 550–6. PMID 16155958. doi:10.1002/mrd.20377. 
  4. ^ "Entrez Gene: NR6A1 nuclear receptor subfamily 6, group A, member 1". 

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