Open Access Articles- Top Results for Giardia
Internal Medicine: Open AccessParasitic Zoo of Fasciolopsis buski, Gastrodiscoides hominis, Giardia intestinalis and Entamoeba histolytica
Journal of Microbial & Biochemical TechnologyMAP Kinases are Required for Apoptosis of HCT-8 Epithelial Cells Induced by the Parasite Giardia intestinalis
Giardia (// or //) is a genus of anaerobic flagellated protozoan parasites of the phylum Sarcomastigophora that colonise and reproduce in the small intestines of several vertebrates, causing giardiasis. Their life cycle alternates between an actively swimming trophozoite and an infective, resistant cyst. Giardia were first described by the Dutch microscopist Antonie van Leeuwenhoek in 1681. The genus is named after French zoologist Alfred Mathieu Giard.
Like other diplomonads, Giardia have two nuclei, each with four associated flagella, and lack both mitochondria and a Golgi apparatus. However they are now known to possess a complex endomembrane system as well as mitochondrial relics, called mitosomes. The mitosomes are not used in ATP synthesis the way mitochondria are, but are involved in the maturation of iron-sulfur proteins. The synapomorphies of genus Giardia include cells with duplicate organelles, absence of cytostomes, and ventral adhesive disc.
Infection and symptoms
Giardia lives inside the intestines of infected humans or other animals. Individuals become infected through ingesting or coming into contact with contaminated food, soil, or water. The Giardia parasite originates from contaminated items and surfaces that have been tainted by the feces of an infected carrier.
The symptoms of Giardia, which may begin to appear 2 days after infection, include violent diarrhea, excess gas, stomach or abdominal cramps, upset stomach, and nausea. Resulting dehydration and nutritional loss may need immediate treatment. The typical infection within an individual can be slight, resolve without treatment, and last between 2–6 weeks, although it can sometimes last longer and/or be more severe. Coexistence with the parasite is possible (symptoms fade), but one can remain a carrier and transmit it to others. Medication containing tinidazole or metronidazole decreases symptoms and time to resolution. Albendazole is also used, and has an anti-helmintic (anti-worm) property as well, ideal for certain compounded issues when a general vermicidal agent is preferred. Giardia causes a disease called Giardiasis which causes the villi of the small intestine to atrophy and flatten, resulting in malabsorption in the intestine. Lactose intolerance can persist after the eradication of Giardia from the digestive tract. 
Person-to-person transmission accounts for the majority of Giardia infections and is usually associated with poor hygiene and sanitation. Giardia is found on the surface of the ground, in the soil, in undercooked foods, and water along with improper cleaning of fecal material from the hands after handling infected feces.  Water-borne transmission is associated with the ingestion of contaminated water. In the U.S., outbreaks typically occur in small water systems using inadequately treated surface water. Venereal transmission happens through fecal-oral contamination. Additionally, diaper changing and inadequate hand washing are risk factors for transmission from infected children. Lastly, food-borne epidemics of Giardia have developed through the contamination of food by infected food-handlers.
About 40 species have been described from different animals, but many of them are probably synonyms. Currently, five to six morphologically distinct species are recognised. Giardia lamblia (=G. intestinalis, =G. duodenalis) infect humans and other mammals, G. muris is found from other mammals, G. ardeae and G. psittaci from birds, G. agilis from amphibians and G. microti from voles. Other described, (but not certainly valid) species include: Many different species of Giardia exist and to discriminate between species very specific PCR (Polymerase Chain Reactions) have been developed to detect specific Giardia spp. Gene probe-based detection is also used to differentiate between species of Giardia. A more common and less time consuming means of identifying different species of Giardia includes microscopy and immunofluorescence techniques. 
A Giardia isolate (WB) was the first diplomonad to have its genome sequenced. Its 11.7 million basepair genome is compact in structure and content with simplified basic cellular machineries and metabolism. Currently the genomes of several other Giardia isolates and diplomonads (the fish pathogens Spironucleus vortens and S. salmonicida) are being sequenced.
A second isolate (the B assemblage) from humans has been sequenced along with a species from a pig (the E assemblage). There are ~5000 genes in the genome. The E assemblage is more closely related to the A assemblage than is the B. A number of chromosomal rearrangements are present.
- Stanley L. Erlandsen; Ernest A. Meyer (1 March 1984). Giardia and Giardiasis: Biology, Pathogenesis, and Epidemiology. Springer. pp. 131–. ISBN 978-0-306-41539-5.
- Adam RD (July 2001). "Biology of Giardia lamblia". Clin. Microbiol. Rev. 14 (3): 447–75. PMC 88984. PMID 11432808. doi:10.1128/CMR.14.3.447-475.2001.
- Soltys BJ, Falah M, Gupta RS (July 1996). "Identification of endoplasmic reticulum in the primitive eukaryote Giardia lamblia using cryoelectron microscopy and antibody to Bip". J. Cell. Sci. 109 (Pt 7): 1909–17. PMID 8832413.
- Dolezal P, Smíd O, Rada P et al. (August 2005). "Giardia mitosomes and trichomonad hydrogenosomes share a common mode of protein targeting". Proc. Natl. Acad. Sci. U.S.A. 102 (31): 10924–9. PMC 1182405. PMID 16040811. doi:10.1073/pnas.0500349102.
- Tovar J. et al. (2003). "Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation". Nature 426 (6963): 172–6. PMID 14614504. doi:10.1038/nature01945.
- Cepicka, Ivan (September 2008). "Tree of Life Web Project".
- Filice, F.P. (1952). "Studies on the cytology and life history of a Giardia from the laboratory rat". U. C. Publications in Zoology (Berkeley CA: University of California Press) 57 (2).
- LaCour 2003
- CDC Giardia 2011
- Giardiasis at eMedicine
- Meyer E.A., Radulescu S. (1979). "Giardia and Giardiasis". Advances in Parasitology 17: 1–47. PMID 395833. doi:10.1016/S0065-308X(08)60548-5.
- Brusca, R.C.; Brusca, G.J. (2003). Invertebrates (2nd ed.). Sinauer Associates. ISBN 0878930973.
- "Giardia Kunstler". Tree of Life Web Project. September 2008.
- Mahbubani 1992
- Thompson RC, Monis PT (2004). "Variation in Giardia: implications for taxonomy and epidemiology". Adv. Parasitol. 58: 69–137. PMID 15603762. doi:10.1016/S0065-308X(04)58002-8.
- Andersson, JO et al. (2010). "The Genome of Giardia and Other Diplomonads". Anaerobic Parasitic Protozoa: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-61-5.
- Jerlström-Hultqvist J, Ankarklev J, Svärd SG (2010). "Is human giardiasis caused by two different Giardia species?". Gut Microbes 1 (6): 379–82. PMC 3056102. PMID 21468219. doi:10.4161/gmic.1.6.13608.
- "Giardia". Parasites. Centers for Disease Control and Prevention. March 2011.
- Mahbubani MH, Bej AK, Perlin MH, Schaefer FW, Jakubowski W, Atlas RM (January 1992). "Differentiation of Giardia duodenalis from other Giardia spp. by using polymerase chain reaction and gene probes". J. Clin. Microbiol. 30 (1): 74–8. PMC 264999. PMID 1734070.
- LaCour, Michelle (2003). "Who Is Giardia?". GIARDIA. Stanford University.
- "Giardia". NCBI Taxonomy Browser. 5740.