Open Access Articles- Top Results for Goodpasture-antigen-binding protein kinase

Goodpasture-antigen-binding protein kinase

Goodpasture-antigen-binding protein kinase
EC number
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MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a Goodpasture-antigen-binding protein kinase (EC is an enzyme that catalyzes the chemical reaction

ATP + Goodpasture antigen-binding protein <math>\rightleftharpoons</math> ADP + [Goodpasture antigen-binding phosphoprotein]

Thus, the two substrates of this enzyme are ATP and Goodpasture antigen-binding protein, whereas its two products are ADP and Goodpasture antigen-binding phosphoprotein.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[Goodpasture antigen-binding protein] phosphotransferase. Other names in common use include GPBPK, GPBP kinase, STK11, and Goodpasture antigen-binding protein kinase. This enzyme participates in mtor signaling pathway and adipocytokine signaling pathway.


  • Raya A, Revert F, Navarro S, Saus J (1999). "Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen". J. Biol. Chem. 274 (18): 12642–9. PMID 10212244. doi:10.1074/jbc.274.18.12642. 
  • Vieites B, Granero F, Forteza J, Saus J (2000). "Goodpasture antigen-binding protein, the kinase that phosphorylates the goodpasture antigen, is an alternatively spliced variant implicated in autoimmune pathogenesis". J. Biol. Chem. 275 (51): 40392–9. PMID 11007769. doi:10.1074/jbc.M002769200. 

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