Open Access Articles- Top Results for Growth-hormone-releasing hormone receptor

Growth-hormone-releasing hormone receptor

External IDsOMIM139191 MGI95710 HomoloGene640 IUPHAR: 247 ChEMBL: 2032 GeneCards: GHRHR Gene
RNA expression pattern
File:PBB GE GHRHR 207825 s at tn.png
File:PBB GE GHRHR 211544 s at tn.png
File:PBB GE GHRHR 211545 at tn.png
More reference expression data
RefSeq (mRNA)NM_000823NM_001003685
RefSeq (protein)NP_000814NP_001003685
Location (UCSC)Chr 7:
30.98 – 31.03 Mb
Chr 6:
55.38 – 55.39 Mb
PubMed search[1][2]

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.[1]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.[2]




  1. ^ Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Recept. Channels 8 (3–4): 155–62. PMID 12529933. doi:10.1080/10606820213679. 
  2. ^ "Entrez Gene: GHRHR growth hormone releasing hormone receptor". 
  3. ^ Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)". Peptides 18 (3): 431–8. PMID 9145432. doi:10.1016/S0196-9781(96)00334-8. 
  4. ^ Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (December 2010). "Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice". Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22272–7. PMC 3009756. PMID 21135231. doi:10.1073/pnas.1016369107. 

Further reading

  • Gaylinn BD (1999). "Molecular and cell biology of the growth hormone-releasing hormone receptor.". Growth Horm. IGF Res. 9 Suppl A: 37–44. PMID 10429879. doi:10.1016/S1096-6374(99)80008-2. 
  • Lin-Su K, Wajnrajch MP (2003). "Growth Hormone Releasing Hormone (GHRH) and the GHRH Receptor.". Reviews in endocrine & metabolic disorders 3 (4): 313–23. PMID 12424433. doi:10.1023/A:1020949507265. 
  • Mayo KE (1992). "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.". Mol. Endocrinol. 6 (10): 1734–44. PMID 1333056. doi:10.1210/me.6.10.1734. 
  • Squire J, Zhou A, Hassel BA et al. (1994). "Localization of the interferon-induced, 2-5A-dependent RNase gene (RNS4) to human chromosome 1q25.". Genomics 19 (1): 174–5. PMID 7514564. doi:10.1006/geno.1994.1033. 
  • Hashimoto K, Koga M, Motomura T et al. (1995). "Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas.". J. Clin. Endocrinol. Metab. 80 (10): 2933–9. PMID 7559877. doi:10.1210/jc.80.10.2933. 
  • Tang J, Lagacé G, Castagné J, Collu R (1995). "Identification of human growth hormone-releasing hormone receptor splicing variants.". J. Clin. Endocrinol. Metab. 80 (8): 2381–7. PMID 7629234. doi:10.1210/jc.80.8.2381. 
  • Gaylinn BD, Harrison JK, Zysk JR et al. (1993). "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.". Mol. Endocrinol. 7 (1): 77–84. PMID 7680413. doi:10.1210/me.7.1.77. 
  • Gaylinn BD, von Kap-Herr C, Golden WL, Thorner MO (1994). "Assignment of the human growth hormone-releasing hormone receptor gene (GHRHR) to 7p14 by in situ hybridization.". Genomics 19 (1): 193–5. PMID 8188233. doi:10.1006/geno.1994.1045. 
  • Wajnrajch MP, Gertner JM, Harbison MD et al. (1996). "Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.". Nat. Genet. 12 (1): 88–90. PMID 8528260. doi:10.1038/ng0196-88. 
  • Netchine I, Talon P, Dastot F et al. (1998). "Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.". J. Clin. Endocrinol. Metab. 83 (2): 432–6. PMID 9467553. doi:10.1210/jc.83.2.432. 
  • Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene.". Mol. Endocrinol. 12 (2): 233–47. PMID 9482665. doi:10.1210/me.12.2.233. 
  • Maheshwari HG, Silverman BL, Dupuis J, Baumann G (1998). "Phenotype and genetic analysis of a syndrome caused by an inactivating mutation in the growth hormone-releasing hormone receptor: Dwarfism of Sindh.". J. Clin. Endocrinol. Metab. 83 (11): 4065–74. PMID 9814493. doi:10.1210/jc.83.11.4065. 
  • Salvatori R, Hayashida CY, Aguiar-Oliveira MH et al. (1999). "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.". J. Clin. Endocrinol. Metab. 84 (3): 917–23. PMID 10084571. doi:10.1210/jc.84.3.917. 
  • Morel G, Gallego R, Boulanger L et al. (2000). "Restricted presence of the growth hormone-releasing hormone receptor to somatotropes in rat and human pituitaries.". Neuroendocrinology 70 (2): 128–36. PMID 10461027. doi:10.1159/000054467. 
  • Rekasi Z, Czompoly T, Schally AV, Halmos G (2000). "Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers.". Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10561–6. PMC 27064. PMID 10962031. doi:10.1073/pnas.180313297. 
  • Salvatori R, Fan X, Phillips JA et al. (2001). "Three new mutations in the gene for the growth hormone (gh)-releasing hormone receptor in familial isolated gh deficiency type ib.". J. Clin. Endocrinol. Metab. 86 (1): 273–9. PMID 11232012. doi:10.1210/jc.86.1.273. 
  • Kiaris H, Schally AV, Busto R et al. (2002). "Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 196–200. PMC 117538. PMID 11773624. doi:10.1073/pnas.012590999. 
  • Salvatori R, Fan X, Mullis PE et al. (2002). "Decreased expression of the GHRH receptor gene due to a mutation in a Pit-1 binding site.". Mol. Endocrinol. 16 (3): 450–8. PMID 11875102. doi:10.1210/me.16.3.450. 
  • Plonowski A, Schally AV, Busto R et al. (2003). "Expression of growth hormone-releasing hormone (GHRH) and splice variants of GHRH receptors in human experimental prostate cancers.". Peptides 23 (6): 1127–33. PMID 12126741. doi:10.1016/S0196-9781(02)00043-8. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.