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Guatemala syphilis experiment

The syphilis experiments in Guatemala were United States-led human experiments conducted in Guatemala from 1946 to 1948, during the administration of President Truman and President Juan José Arévalo with the cooperation of some Guatemalan health ministries and officials.[1] Doctors infected soldiers, prostitutes, prisoners and mental patients with syphilis and other sexually transmitted diseases, without the informed consent of the subjects, and treated most subjects with antibiotics. This resulted in at least 83 deaths.[2] In October 2010, the U.S. formally apologized to Guatemala for conducting these experiments.


The experiments were led by United States Public Health Service physician John Charles Cutler, who later took part in the late stages of the Tuskegee syphilis experiment.[3] In archived documents, Dr. Thomas Parran, Jr., the U.S. Surgeon General at the time of the experiments, acknowledged that the Guatemalan work could not be done domestically, and details were hidden from Guatemalan officials.[4][5] Some letters between Cutler and John Mahoney, then Medical Director of the USPHS can be seen here.[6]

The experiments even involved young orphan girls sourced from a Catholic charity as victims. The nature of some experiments would have involved labial penetration of a child.[7] Details on one death from the experiments read

Cutler and his colleagues treated some people brutally. In one case, detailed by the bioethics commission, the US doctors infected a woman named Berta, a patient at the psychiatric hospital, with syphilis, but did not treat her for three months. Her health worsened, and within another three months Cutler reported that she seemed close to death. He re-infected Berta with syphilis, and inserted pus from someone with gonorrhoea into her eyes, urethra and rectum. Over several days, pus developed in Berta's eyes, she started bleeding from her urethra and then she died.

The experiments were funded by a grant from the U.S. National Institutes of Health (NIH) to the Pan American Sanitary Bureau and involved multiple Guatemalan government ministries.[1] A total of about 1500 study subjects were involved although the findings were never published.[1]

Information about these experiments was uncovered by Professor Susan Mokotoff Reverby of Wellesley College. Reverby found the documents in 2005 while researching the Tuskegee syphilis study, in Cutler's archived papers, and shared her findings with United States government officials.[1][4]

While the Tuskegee experiment followed the natural progression of syphilis in those already infected, in Guatemala doctors deliberately infected healthy people with the diseases, some of which can be fatal if untreated. The goal of the study seems to have been to determine the effect of penicillin in the prevention and treatment of venereal diseases. The researchers paid prostitutes infected with syphilis to have sex with prisoners and some subjects were infected by directly inoculating them with the bacterium.[1] When the subjects contracted the disease they were given antibiotics. Although adequate penicillin therapy was prescribed for 76% of subjects, completion of therapy was documented for only 26%.[citation needed] Francis Collins, the NIH director at the time of the revelations, called the experiments "a dark chapter in history of medicine" and commented that modern rules prohibit conducting human subject research without informed consent.[9]

The study appears to have ended in 1948, partly because of medical “gossip” about the work, and partly because penicillin was very costly. However, some follow-up laboratory testing and patient observation continued until the early 1950s.

Additionally, similar research was also conducted on the transmission and prophylaxis of gonorrhea and chancroid.[10] The subjects for all of the STD experiments consisted of female sex workers, prisoners, soldiers, and mental hospital patients; the Centers for Disease Control and Prevention acknowledges that "the design and conduct of the studies was unethical in many respects, including deliberate exposure of subjects to known serious health threats, lack of knowledge of and consent for experimental procedures by study subjects, and the use of highly vulnerable populations."[10]

Apology and response

In October 2010, the U.S. government formally apologized and announced that the violation of human rights in that medical research was still to be condemned, regardless of how much time had passed.[11][12][13] In a joint statement, Hillary Clinton and Kathleen Sebelius said:
Although these events occurred more than 64 years ago, we are outraged that such reprehensible research could have occurred under the guise of public health. We deeply regret that it happened, and we apologize to all the individuals who were affected by such abhorrent research practices. The conduct exhibited during the study does not represent the values of the US, or our commitment to human dignity and great respect for the people of Guatemala.[14]
President Barack Obama apologized to President Álvaro Colom, who had called these experiments "a crime against humanity".[15]

"It is clear from the language of the report that the U.S. researchers understood the profoundly unethical nature of the study. In fact the Guatemalan syphilis study was being carried out just as the “Doctors’ Trial” was unfolding at Nuremberg (December 1946 – August 1947), when 23 German physicians stood trial for participating in Nazi programs to euthanize or medically experiment on concentration camp prisoners."[16]

The U.S. government asked the Institute of Medicine to conduct a review of these experiments.[1] Separately, the Presidential Commission for the Study of Bioethical Issues was asked to convene a panel of international experts to review the current state of medical research on humans around the world and ensure that such incidents cannot be repeated.[1] The Commission report, Ethically Impossible: STD Research in Guatemala from 1946 to 1948, published in September 2011, concluded that "the Guatemala experiments involved unconscionable basic violations of ethics, even as judged against the researchers' own recognition of the requirements of the medical ethics of the day."[17][18]

Human rights activists have called for subjects' families to be compensated.[3]

See also

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  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 "Fact Sheet on the 1946-1948 U.S. Public Health Service Sexually Transmitted Diseases (STD) Inoculation Study". United States Department of Health and Human Services. nd. Retrieved 2013-04-15. 
  2. "Guatemalans 'died' in 1940s US syphilis study". BBC News. 29 August 2011. Retrieved 29 August 2011. 
  3. 3.0 3.1 Chris McGreal (1 October 2010). "US says sorry for "outrageous and abhorrent" Guatemalan syphilis tests". The Guardian. Retrieved 2 October 2010. Conducted between 1946 and 1948, the experiments were led by John Cutler, a US health service physician who would later be part of the notorious Tuskegee syphilis study in Alabama in the 1960s. 
  4. 4.0 4.1 "Wellesley professor unearths a horror: Syphilis experiments in Guatemala". Boston Globe. 1 October 2010. Retrieved 2 October 2010. 
  5. "Exposed: US Doctors Secretly Infected Hundreds of Guatemalans with Syphilis in the 1940s". Democracy Now!. 5 October 2010. Retrieved 12 July 2011. 
  8. Walter, Mathew (8 February 2012). "Human experiments: First, do harm". Nature. Retrieved 9 April 2015. 
  9. Donald G. McNeil, Jr. (1 October 2010). "U.S. Apologizes for Syphilis Tests in Guatemala". The New York Times. Retrieved 2 October 2010. 
  10. 10.0 10.1 "Findings from a CDC Report on the 1946-1948 U.S. Public Health Service Sexually Transmitted Disease (STD) Inoculation Study", U.S. Department of Health & Human Services, 30 September 2010
  11. "U.S. Apologizes For Syphilis Experiments In Guatemala". National Public Radio. 1 October 2010. Retrieved 1 October 2010. 
  12. "U.S. apologizes for newly revealed syphilis experiments done in Guatemala". Washington Post. 1 October 2010. Retrieved 1 October 2010. The United States issued an unusual apology Friday to Guatemala for conducting experiments in the 1940s in which doctors infected soldiers, prisoners and mental patients with syphilis and other sexually transmitted diseases. 
  14. "Joint Statement by Secretaries Clinton and Sebelius on a 1946-1948 Study", U.S. Department of Health & Human Services, October 1, 2010
  15. "US medical tests in Guatemala 'crime against humanity'". BBC News. 1 October 2010. Retrieved 2 October 2010. 
  16. Nate, Jones. "Decades Later, NARA Posts Documents on Guatemalan Syphilis Experiments". NSA Archive. The George Washington University. Retrieved 21 March 2012. 
  17. Ethically Impossible: STD Research in Guatemala from 1946 to 1948, Presidential Commission for the Study of Bioethical Issues, published 2011-09-13, accessed 2012-08-29
  18. "Lapses by American Leaders Seen in Syphilis Tests", Donald G. McNeil Jr., New York Times, September 14, 2011

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