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HCN2

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Identifiers
SymbolsHCN2 ; BCNG-2; BCNG2; HAC-1
External IDsOMIM602781 MGI1298210 HomoloGene31022 IUPHAR: 401 ChEMBL: 1795172 GeneCards: HCN2 Gene
RNA expression pattern
File:PBB GE HCN2 207592 s at tn.png
File:PBB GE HCN2 214893 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez61015166
EnsemblENSG00000099822ENSMUSG00000020331
UniProtQ9UL51O88703
RefSeq (mRNA)NM_001194NM_008226
RefSeq (protein)NP_001185NP_032252
Location (UCSC)Chr 19:
0.59 – 0.62 Mb
Chr 10:
79.72 – 79.74 Mb
PubMed search[1][2]

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 2 is a protein that in humans is encoded by the HCN2 gene.[1][2][3][4]

Interactions

HCN2 has been shown to interact with HCN1[5][6] and HCN4.[5]

Function

The function of the channel is not known although its activation by hyperpolarization alludes to the funny channels in the sinoatrial node of the heart (which form the basis of spontaneous generation of electrical rhythm). These channels have recently been associated with chronic pain and blocking the gene is associated with resolution of neuropathic episodes of pain.[7]

See also

References

  1. ^ Santoro B, Grant SG, Bartsch D, Kandel ER (Dec 1997). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14815–20. PMC 25120. PMID 9405696. doi:10.1073/pnas.94.26.14815. 
  2. ^ Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA et al. (May 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717–29. PMID 9630217. doi:10.1016/S0092-8674(00)81434-8. 
  3. ^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacological Reviews 57 (4): 455–62. PMID 16382102. doi:10.1124/pr.57.4.8. 
  4. ^ "Entrez Gene: HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2". 
  5. ^ a b Much B, Wahl-Schott C, Zong X, Schneider A, Baumann L, Moosmang S et al. (Oct 2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". The Journal of Biological Chemistry 278 (44): 43781–6. PMID 12928435. doi:10.1074/jbc.M306958200. 
  6. ^ Proenza C, Tran N, Angoli D, Zahynacz K, Balcar P, Accili EA (Aug 2002). "Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels". The Journal of Biological Chemistry 277 (33): 29634–42. PMID 12034718. doi:10.1074/jbc.M200504200. 
  7. ^ "Gene find may lead to pills that kill chronic pain". The Times Of India. 10 September 2011. 


Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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