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HIVEP3

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Identifiers
SymbolsHIVEP3 ; KBP-1; KBP1; KRC; SHN3; Schnurri-3; ZAS3; ZNF40C
External IDsOMIM606649 MGI106589 HomoloGene7803 GeneCards: HIVEP3 Gene
RNA expression pattern
File:PBB GE HIVEP3 220042 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez5926916656
EnsemblENSG00000127124ENSMUSG00000028634
UniProtQ5T1R4A2A884
RefSeq (mRNA)NM_001127714NM_010657
RefSeq (protein)NP_001121186NP_034787
Location (UCSC)Chr 1:
41.97 – 42.5 Mb
Chr 4:
119.73 – 120.14 Mb
PubMed search[1][2]

Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.[1][2]

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][2]

Interactions

HIVEP3 has been shown to interact with TRAF1[3] and TRAF2.[3]

References

  1. ^ Hicar MD, Liu Y, Allen CE, Wu LC (Feb 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics 71 (1): 89–100. PMID 11161801. doi:10.1006/geno.2000.6425. 
  2. ^ a b "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3". 
  3. ^ a b Oukka, Mohamed; Kim Sean T; Lugo Geancarlo; Sun Jenny; Wu Lai-Chu; Glimcher Laurie H (Jan 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Mol. Cell (United States) 9 (1): 121–31. ISSN 1097-2765. PMID 11804591. doi:10.1016/S1097-2765(01)00434-8. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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