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Open Access Articles- Top Results for HLF (gene)

HLF (gene)

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Identifiers
SymbolsHLF ; MGC33822
External IDsOMIM142385 MGI96108 HomoloGene31074 GeneCards: HLF Gene
RNA expression pattern
File:PBB GE HLF 204753 s at tn.png
File:PBB GE HLF 204754 at tn.png
File:PBB GE HLF 204755 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez3131217082
EnsemblENSG00000108924ENSMUSG00000003949
UniProtQ16534Q8BW74
RefSeq (mRNA)NM_002126NM_172563
RefSeq (protein)NP_002117NP_766151
Location (UCSC)Chr 17:
53.34 – 53.4 Mb
Chr 11:
90.34 – 90.39 Mb
PubMed search[1][2]

Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[1][2]

This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[2]

References

  1. ^ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (Aug 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science 257 (5069): 531–4. PMID 1386162. doi:10.1126/science.1386162. 
  2. ^ a b "Entrez Gene: HLF hepatic leukemia factor". 

Further reading

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External links


Template:Gene-17-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.