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HMGB2

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Identifiers
SymbolsHMGB2 ; HMG2
External IDsOMIM163906 MGI96157 HomoloGene37582 GeneCards: HMGB2 Gene
RNA expression pattern
File:PBB GE HMGB2 208808 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez314897165
EnsemblENSG00000164104ENSMUSG00000054717
UniProtP26583P30681
RefSeq (mRNA)NM_001130688NM_008252
RefSeq (protein)NP_001124160NP_032278
Location (UCSC)Chr 4:
174.25 – 174.26 Mb
Chr 8:
57.51 – 57.52 Mb
PubMed search[1][2]

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.[1][2]

Function

This gene encodes a member of the non-histone chromosomal high-mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination.[2]

References

  1. ^ Majumdar A, Brown D, Kerby S, Rudzinski I, Polte T, Randhawa Z, Seidman MM (Jan 1992). "Sequence of human HMG2 cDNA". Nucleic Acids Res 19 (23): 6643. PMC 329240. PMID 1754403. doi:10.1093/nar/19.23.6643. 
  2. ^ a b "Entrez Gene: HMGB2 high-mobility group box 2". 

Further reading

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External links


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