Open Access Articles- Top Results for HOXA11


SymbolsHOXA11 ; HOX1; HOX1I
External IDsOMIM142958 MGI96172 HomoloGene4033 GeneCards: HOXA11 Gene
RNA expression pattern
File:PBB GE HOXA11 208493 at tn.png
File:PBB GE HOXA11 213823 at tn.png
More reference expression data
RefSeq (mRNA)NM_005523NM_010450
RefSeq (protein)NP_005514NP_034580
Location (UCSC)Chr 7:
27.22 – 27.22 Mb
Chr 6:
52.24 – 52.25 Mb
PubMed search[1][2]

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia.[3]

See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ a b "Entrez Gene: HOXA11 homeobox A11". 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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