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HOXA13

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsHOXA13 ; HOX1; HOX1J
External IDsOMIM142959 MGI96173 HomoloGene73882 GeneCards: HOXA13 Gene
RNA expression pattern
File:PBB GE HOXA13 gnf1h00031 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez320915398
EnsemblENSG00000106031ENSMUSG00000038203
UniProtP31271Q62424
RefSeq (mRNA)NM_000522NM_008264
RefSeq (protein)NP_000513NP_032290
Location (UCSC)Chr 7:
27.23 – 27.24 Mb
Chr 6:
52.26 – 52.26 Mb
PubMed search[1][2]

Homeobox protein Hox-A13 is a protein that in humans is encoded by the HOXA13 gene.[1][2][3]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.[3]

Clinical significance

Expansion of a polyalanine tract in the encoded protein can cause hand-foot-genital syndrome , also known as hand-foot-uterus syndrome.[4]

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ a b "Entrez Gene: HOXA13 homeobox A13". 
  4. ^ Innis, Jeffrey W (2006-07-11). Hand-Foot-Genital Syndrome. NCBI Bookshelf, GeneReviews. University of Washington, Seattle. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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