Open Access Articles- Top Results for HOXA3


SymbolsHOXA3 ; HOX1; HOX1E
External IDsOMIM142954 MGI96175 HomoloGene40725 GeneCards: HOXA3 Gene
RNA expression pattern
File:PBB GE HOXA3 208604 s at tn.png
More reference expression data
RefSeq (mRNA)NM_030661NM_010452
RefSeq (protein)NP_109377NP_034582
Location (UCSC)Chr 7:
27.15 – 27.19 Mb
Chr 6:
52.16 – 52.21 Mb
PubMed search[1][2]

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[3]


The HOXA3 gene is repressed by the microRNA miR-10a.[4]

See also


  1. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. 3.0 3.1 "Entrez Gene: HOXA3 homeobox A3". 
  4. Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007). "DNA methylation regulates MicroRNA expression". Cancer Biol Ther 6 (8): 1284–8. PMID 17660710. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Lua error in package.lua at line 80: module 'Module:Buffer' not found.