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HOXA3

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsHOXA3 ; HOX1; HOX1E
External IDsOMIM142954 MGI96175 HomoloGene40725 GeneCards: HOXA3 Gene
RNA expression pattern
File:PBB GE HOXA3 208604 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez320015400
EnsemblENSG00000105997ENSMUSG00000079560
UniProtO43365P02831
RefSeq (mRNA)NM_030661NM_010452
RefSeq (protein)NP_109377NP_034582
Location (UCSC)Chr 7:
27.15 – 27.19 Mb
Chr 6:
52.16 – 52.21 Mb
PubMed search[1][2]

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.[1][2][3]

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.[3]

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a.[4]

See also

References

  1. McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. 3.0 3.1 "Entrez Gene: HOXA3 homeobox A3". 
  4. Han L, Witmer PD, Casey E, Valle D, Sukumar S (2007). "DNA methylation regulates MicroRNA expression". Cancer Biol Ther 6 (8): 1284–8. PMID 17660710. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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