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HOXB1

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Identifiers
SymbolsHOXB1 ; HCFP3; HOX2; HOX2I; Hox-2.9
External IDsOMIM142968 MGI96182 HomoloGene1615 GeneCards: HOXB1 Gene
RNA expression pattern
File:PBB GE HOXB1 208224 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez321115407
EnsemblENSG00000120094ENSMUSG00000018973
UniProtP14653P17919
RefSeq (mRNA)NM_002144NM_008266
RefSeq (protein)NP_002135NP_032292
Location (UCSC)Chr 17:
46.61 – 46.61 Mb
Chr 11:
96.37 – 96.37 Mb
PubMed search[1][2]

Homeobox protein Hox-B1 is a protein that in humans is encoded by the HOXB1 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17.[3]

Interactions

HOXB1 has been shown to interact with PBX1.[4][5]

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ a b "Entrez Gene: HOXB1 homeobox B1". 
  4. ^ Berthelsen J, Zappavigna V, Ferretti E, Mavilio F, Blasi F (Mar 1998). "The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity". EMBO J. 17 (5): 1434–45. PMC 1170491. PMID 9482740. doi:10.1093/emboj/17.5.1434. 
  5. ^ Piper DE, Batchelor AH, Chang CP, Cleary ML, Wolberger C (Feb 1999). "Structure of a HoxB1-Pbx1 heterodimer bound to DNA: role of the hexapeptide and a fourth homeodomain helix in complex formation". Cell 96 (4): 587–97. PMID 10052460. doi:10.1016/S0092-8674(00)80662-5. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.Template:Gene-17-stub