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HOXB7

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Identifiers
SymbolsHOXB7 ; HHO.C1; HOX2; HOX2C; Hox-2.3
External IDsOMIM142962 MGI96188 HomoloGene55828 GeneCards: HOXB7 Gene
RNA expression pattern
File:PBB GE HOXB7 216973 s at tn.png
File:PBB GE HOXB7 204778 x at tn.png
File:PBB GE HOXB7 204779 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez321715415
EnsemblENSG00000260027ENSMUSG00000038721
UniProtP09629P09024
RefSeq (mRNA)NM_004502NM_010460
RefSeq (protein)NP_004493NP_034590
Location (UCSC)Chr 17:
48.61 – 48.63 Mb
Chr 11:
96.29 – 96.29 Mb
PubMed search[1][2]

Homeobox protein Hox-B7 is a protein that in humans is encoded by the HOXB7 gene.[1][2]

Function

This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.[3]

Interactions

HOXB7 has been shown to interact with PBX1[4] and CREB-binding protein.[5]

See also

References

  1. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ "Entrez Gene: HOXB7 homeobox B7". 
  4. ^ Chang CP, Shen WF, Rozenfeld S, Lawrence HJ, Largman C, Cleary ML (March 1995). "Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins". Genes Dev. 9 (6): 663–74. PMID 7729685. doi:10.1101/gad.9.6.663. 
  5. ^ Chariot A, van Lint C, Chapelier M, Gielen J, Merville MP, Bours V (July 1999). "CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein". Oncogene 18 (27): 4007–14. PMID 10435624. doi:10.1038/sj.onc.1202776. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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