Open Access Articles- Top Results for HOXB8


SymbolsHOXB8 ; HOX2; HOX2D; Hox-2.4
External IDsOMIM142963 MGI96189 HomoloGene7768 GeneCards: HOXB8 Gene
RNA expression pattern
File:PBB GE HOXB8 221278 at tn.png
File:PBB GE HOXB8 204778 x at tn.png
More reference expression data
RefSeq (mRNA)NM_024016NM_010461
RefSeq (protein)NP_076921NP_034591
Location (UCSC)Chr 17:
46.69 – 46.69 Mb
Chr 11:
96.28 – 96.29 Mb
PubMed search[1][2]

Homeobox protein Hox-B8 is a protein that in humans is encoded by the HOXB8 gene.[1][2][3]

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of Homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog (see Homology (biology) § Orthology) of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania.[3]

Transplantation of normal (wild-type) bone marrow into a Hoxb8 mutant mouse results is a reduction of compulsive grooming.[4]

See also


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ a b "Entrez Gene: HOXB8 homeobox B8". 
  4. ^ Shau-Kwaun Chen, Petr Tvrdik, Erik Peden, Scott Cho, Sen Wu1, Gerald Spangrude and Mario R. Capecchi (May 2010). "Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice". Cell 141 (5): 775–785. PMC 2894573. PMID 20510925. doi:10.1016/j.cell.2010.03.055. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.Template:Gene-17-stub