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HOXB9

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsHOXB9 ; HOX-2.5; HOX2; HOX2E
External IDsOMIM142964 MGI96190 HomoloGene7367 GeneCards: HOXB9 Gene
RNA expression pattern
File:PBB GE HOXB9 216417 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez321915417
EnsemblENSG00000170689ENSMUSG00000020875
UniProtP17482P20615
RefSeq (mRNA)NM_024017NM_008270
RefSeq (protein)NP_076922NP_032296
Location (UCSC)Chr 17:
46.7 – 46.7 Mb
Chr 11:
96.27 – 96.28 Mb
PubMed search[1][2]

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.[1][2][3]

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.[3]

Interactions

HOXB9 has been shown to interact with BTG2[4] and BTG1.[4]

See also

References

  1. McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. 3.0 3.1 "Entrez Gene: HOXB9 homeobox B9". 
  4. 4.0 4.1 Prévôt D, Voeltzel T, Birot AM, Morel AP, Rostan MC, Magaud JP et al. (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. 275 (1): 147–53. PMID 10617598. doi:10.1074/jbc.275.1.147. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.Template:Gene-17-stub