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HOXD12

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsHOXD12 ; HOX4H
External IDsOMIM142988 MGI96204 HomoloGene7369 GeneCards: HOXD12 Gene
RNA expression pattern
File:PBB GE HOXD12 221411 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez323815432
EnsemblENSG00000170178ENSMUSG00000001823
UniProtP35452P23812
RefSeq (mRNA)NM_021193NM_008274
RefSeq (protein)NP_067016NP_032300
Location (UCSC)Chr 2:
176.96 – 176.97 Mb
Chr 2:
74.67 – 74.68 Mb
PubMed search[1][2]

Homeobox protein Hox-D12 is a protein that in humans is encoded by the HOXD12 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd12 gene plays a role in axial skeleton development and forelimb morphogenesis.[4]

See also

References

  1. ^ D'Esposito M, Morelli F, Acampora D, Migliaccio E, Simeone A, Boncinelli E (July 1991). "EVX2, a human homeobox gene homologous to the even-skipped segmentation gene, is localized at the 5' end of HOX4 locus on chromosome 2". Genomics 10 (1): 43–50. PMID 1675198. doi:10.1016/0888-7543(91)90482-T. 
  2. ^ McAlpine PJ, Shows TB (August 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  3. ^ "Entrez Gene: HOXD12 homeobox D12". 
  4. ^ Davis AP, Capecchi MR (1 April 1996). "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development 122 (4): 1175–85. PMID 8620844. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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