Open Access Articles- Top Results for HOXD8


SymbolsHOXD8 ; HOX4; HOX4E; HOX5.4
External IDsOMIM142985 MGI96209 HomoloGene10473 GeneCards: HOXD8 Gene
RNA expression pattern
File:PBB GE HOXD8 gnf1h00326 at tn.png
More reference expression data
RefSeq (mRNA)NM_001199746NM_001290730
RefSeq (protein)NP_001186675NP_001277659
Location (UCSC)Chr 2:
176.99 – 177 Mb
Chr 2:
74.7 – 74.71 Mb
PubMed search[1][2]

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[1][2][3]

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[3]


  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ a b "Entrez Gene: HOXD8 homeobox D8". 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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