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HOXD9

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Identifiers
SymbolsHOXD9 ; HOX4; HOX4C; Hox-4.3; Hox-5.2
External IDsOMIM142982 MGI96210 HomoloGene8409 GeneCards: HOXD9 Gene
RNA expression pattern
File:PBB GE HOXD9 205604 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez323515438
EnsemblENSG00000128709ENSMUSG00000043342
UniProtP28356P28357
RefSeq (mRNA)NM_014213NM_013555
RefSeq (protein)NP_055028NP_038583
Location (UCSC)Chr 2:
176.99 – 176.99 Mb
Chr 2:
74.7 – 74.7 Mb
PubMed search[1][2]

Homeobox protein Hox-D9 is a protein that in humans is encoded by the HOXD9 gene.[1][2][3]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The exact role of this gene has not been determined.[3]

See also

References

  1. ^ McAlpine PJ, Shows TB (Aug 1990). "Nomenclature for human homeobox genes". Genomics 7 (3): 460. PMID 1973146. doi:10.1016/0888-7543(90)90186-X. 
  2. ^ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. PMID 1358459. doi:10.1016/0092-8674(92)90588-4. 
  3. ^ a b "Entrez Gene: HOXD9 homeobox D9". 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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