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HSF2

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsHSF2 ; HSF 2; HSTF 2
External IDsOMIM140581 MGI96239 HomoloGene37931 GeneCards: HSF2 Gene
RNA expression pattern
File:PBB GE HSF2 209657 s at tn.png
File:PBB GE HSF2 211220 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez329815500
EnsemblENSG00000025156ENSMUSG00000019878
UniProtQ03933P38533
RefSeq (mRNA)NM_001135564NM_008297
RefSeq (protein)NP_001129036NP_032323
Location (UCSC)Chr 6:
122.72 – 122.75 Mb
Chr 10:
57.49 – 57.51 Mb
PubMed search[1][2]

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.[1][2]

Function

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.[2]

Interactions

HSF2 has been shown to interact with Nucleoporin 62[3] and HSF1.[4]

See also

References

  1. ^ Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (Sep 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc Natl Acad Sci U S A 88 (16): 6911–5. PMC 52203. PMID 1871106. doi:10.1073/pnas.88.16.6911. 
  2. ^ a b "Entrez Gene: HSF2 heat shock transcription factor 2". 
  3. ^ Yoshima T, Yura T, Yanagi H (Nov 1997). "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62". Biochem. Biophys. Res. Commun. 240 (1): 228–33. PMID 9367915. doi:10.1006/bbrc.1997.7662. 
  4. ^ He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J et al. (Sep 2003). "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress". J. Biol. Chem. 278 (37): 35465–75. PMID 12813038. doi:10.1074/jbc.M304663200. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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