Open Access Articles- Top Results for Haemorrhagic disease of the newborn

Haemorrhagic disease of the newborn

Not to be confused with Hemolytic disease of the newborn.
Haemorrhagic disease of the newborn
Classification and external resources
ICD-10 P53
ICD-9 776.0
DiseasesDB 29544
MedlinePlus 007320
eMedicine ped/966
NCI Haemorrhagic disease of the newborn
Patient UK Haemorrhagic disease of the newborn
MeSH D006475

Haemorrhagic disease of the newborn, also known as Vitamin K Deficiency Bleeding (VKDB) is a coagulation disturbance in newborns due to vitamin K deficiency. As a consequence of vitamin K deficiency there is an impaired production of coagulation factors II, VII, IX, X, protein C and protein S by the liver.

Signs and symptoms

The disease causes an increased risk of bleeding. The most common sites of bleeding are the umbilicus, mucous membranes, gastrointestinal tract, circumcision and venepunctures.


Newborns are relatively vitamin K deficient for a variety of reasons. They have low vitamin K stores at birth, vitamin K passes the placenta poorly, the levels of vitamin K in breast milk are low and the gut flora has not yet been developed (vitamin K is normally produced by intestinal bacteria).


Treatment consists of vitamin K supplementation.[1] This is often given prophylactically to newborns shortly after birth.


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