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Hexobarbital

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Hexobarbital
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Systematic (IUPAC) name
(RS)-5-(cyclohex-1-en-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione
Clinical data
Pharmacokinetic data
Protein binding 25%
Identifiers
56-29-1 7pxY
50-09-9 (sodium salt)
N01AF02 N05CA16
PubChem CID 3608
DrugBank DB01355 7pxY
ChemSpider 3482 7pxY
UNII AL8Z8K3P6S 7pxY
KEGG D01071 7pxY
ChEBI CHEBI:5706 7pxY
ChEMBL CHEMBL7728 7pxY
Chemical data
Formula C12H16N2O3
236.267 g/mol
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Hexobarbital (as known in the US), or hexobarbitone (as known elsewhere), sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal (usually in 250-mgm. strength tablets), is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s-1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of effects and short duration of action. However it can be difficult to control the depth of anesthesia with hexobarbital which makes it quite dangerous, and it has now been replaced by safer drugs in human medicine; usually thiopental would be the barbiturate of choice for this application these days. Hexobarbital is still used in some scientific research.

Further reading