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Histamine N-methyltransferase

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Identifiers
SymbolsHNMT ; HMT; HNMT-S1; HNMT-S2
External IDsOMIM605238 HomoloGene5032 GeneCards: HNMT Gene
EC number2.1.1.8
Orthologs
SpeciesHumanMouse
Entrez3176140483
EnsemblENSG00000150540ENSMUSG00000026986
UniProtP50135Q91VF2
RefSeq (mRNA)NM_001024074NM_080462
RefSeq (protein)NP_001019245NP_536710
Location (UCSC)Chr 2:
138.72 – 138.77 Mb
Chr 2:
24 – 24.05 Mb
PubMed search[1][2]
histamine N-methyltransferase
Identifiers
EC number 2.1.1.8
CAS number 9029-80-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

Histamine N-methyltransferase (HMT, HNMT) is an enzyme that in humans is encoded by the HNMT gene.[1]

Histamine N-methyltransferase is one of two enzymes involved in the metabolism of histamine, the other being diamine oxidase. Histamine N-methyltransferase catalyzes the methylation of histamine in the presence of S-adenosylmethionine (SAM) forming N-methylhistamine. HMT is present in most body tissues but is not present in serum.[2] Histamine N-methyltransferase is encoded by a single gene which has been mapped to chromosome 2.

Function

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.[1]

References

  1. ^ a b "Entrez Gene: Histamine N-methyltransferase". 
  2. ^ Brown DD, Tomchick R, Axelrod J (November 1959). "The distribution and properties of a histamine-methylating enzyme" (PDF). J. Biol. Chem. 234 (11): 2948–50. PMID 13804910. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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