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Open Access Articles- Top Results for Histamine trifluoromethyl toluidide

Histamine trifluoromethyl toluidide

Histamine trifluoromethyl toluidide
260px
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IUPAC name
6-[2-(3H-imidazol-4-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]heptanamide
Other names
HTMT
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103827-16-3 7pxY
ChemSpider 111155 7pxN
IUPHAR ligand 1273
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C19H25F3N4O
Molar mass 382.42321
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

Histamine trifluoromethyl toluidide (HTMT) is a mixed H1/H2 histamine agonist which is significantly more potent than histamine itself.[1]

It also produces additional actions which appear to be independent of histamine receptors.[2][3]

References

  1. ^ Whyment AD, Blanks AM, Lee K, Renaud LP, Spanswick D. Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. Journal of Neurophysiology. 2006 Apr;95(4):2492-500. PMID 16354729
  2. ^ Qiu R, Melmon KL, Khan MM. Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of Pharmacology and Experimental Therapeutics. 1990 Jun;253(3):1245-52. PMID 2359026
  3. ^ Kim DC, Lee SY, Jun DJ, Kim SH, Lee JH, Hur EM, Baek NI, Kim KT. Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors. Biochemical Pharmacology. 2005 Nov 25;70(11):1613-22. PMID 16219299


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