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Open Access Articles- Top Results for Homotaurine

Homotaurine

Homotaurine[1]
Skeletal formula
Ball-and-stick model
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IUPAC name
3-Aminopropane-1-sulfonic acid
Other names
Tramiprosate; Alzhemed; 3-APS
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3687-18-1 7pxY
ChEMBL ChEMBL149082 7pxY
ChemSpider 1584 7pxY
Jmol-3D images Image
KEGG D06202 7pxY
PubChem Template:Chembox PubChem/format
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C3H9NO3S
Molar mass Lua error in Module:Math at line 495: attempt to index field 'ParserFunctions' (a nil value). g·mol−1
Melting point Script error: No such module "convert". (decomposition)
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R-phrases R36/37/38
S-phrases S26 S36
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxY verify (what is10pxY/10pxN?)
Infobox references

Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. Because of its similarity in structure to the neurotransmitter gamma-aminobutyric acid (GABA), it has GABAergic effects and may be useful as an anticonvulsant.[2]

Homotaurine has also been investigated as a potential treatment for Alzheimer's disease.[3] It binds to soluble amyloid beta and inhibits the formation of neurotoxic aggregates that lead to amyloid plaque deposition in the brain.[4] However, clinical trials failed to show improvement compared to placebo.[5][6][7]

Homotaurine is a zwitterion at neutral pH.

The zwitterionic form of homotaurine

See also

References

  1. ^ Homotaurine at Sigma-Aldrich
  2. ^ Fariello RG, Golden GT, Pisa M; Golden; Pisa (1982). "Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid". Neurology 32 (3): 241–5. PMID 7199633. doi:10.1212/wnl.32.3.241. 
  3. ^ Gauthier, S; Aisen, P. S.; Ferris, S. H.; Saumier, D; Duong, A; Haine, D; Garceau, D; Suhy, J; Oh, J; Lau, W; Sampalis, J (2009). "Effect of tramiprosate in patients with mild-to-moderate Alzheimer's disease: Exploratory analyses of the MRI sub-group of the Alphase study". The journal of nutrition, health & aging 13 (6): 550–7. PMID 19536424. 
  4. ^ Aisen PS, Gauthier S, Vellas B et al. (2007). "Alzhemed: a potential treatment for Alzheimer's disease". Curr Alzheimer Res 4 (4): 473–8. PMID 17908052. doi:10.2174/156720507781788882. 
  5. ^ "Tramiprosate Falls Short in Phase III Alzheimer's Trial". Clinical Psychiatry News. November 1, 2007. 
  6. ^ "Drugs In Clinical Trials : Alzhemed". Alzheimer Research Forum. Retrieved 1 October 2011. 
  7. ^ "Analysts Skeptical Of Neurochem's Efforts To Salvage Value From Alzhemed". Canada National Post. November 13, 2007. Retrieved 1 October 2011. 



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