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Open Access Articles- Top Results for Hydroxydione

Hydroxydione

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Hydroxydione
File:Hydroxydione.svg
Systematic (IUPAC) name
(5β)-21-Hydroxypregnane-3,20-dione
Clinical data
Identifiers
303-01-5
None
PubChem CID 257630
DrugBank DB08956 7pxN
ChemSpider 226020
Chemical data
Formula C21H32O3
332.477 g/mol

Hydroxydione, as hydroxydione sodium succinate (INN, USAN, BAN; brand names Viadril, Predion, and Presuren),[1][2][3] is a neuroactive steroid which was formerly used as a general anesthetic, but was discontinued due to incidence of thrombophlebitis.[4] It was introduced in 1957,[3] and was the first neuroactive steroid general anesthetic to be introduced for clinical use, an event which was shortly preceded by the observation of the sedative properties of progesterone in mice.[5]

See also

References

  1. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 531–. ISBN 978-3-88763-075-1. 
  2. ^ Ashutosh Kar (1 January 2005). Medicinal Chemistry. New Age International. pp. 63–. ISBN 978-81-224-1565-0. 
  3. ^ a b William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 1863–. ISBN 978-0-8155-1856-3. 
  4. ^ Edmond I Eger II; Lawrence Saidman; Rod Westhorpe (14 September 2013). The Wondrous Story of Anesthesia. Springer Science & Business Media. pp. 632–. ISBN 978-1-4614-8441-7. 
  5. ^ Ralph I. Dorfman (22 October 2013). Steroidal Activity in Experimental Animals and Man. Elsevier Science. pp. 447–. ISBN 978-1-4832-7299-3. 



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