Open Access Articles- Top Results for Hyperoxia


Hyperoxia occurs when tissues and organs are exposed to an excess supply of oxygen (O2) or higher than normal partial pressure of oxygen.[1]

In medicine, it refers to excess oxygen in the lungs or other body tissues, which can be caused by breathing air or oxygen at pressures greater than normal atmospheric pressure. This kind of hyperoxia can lead to oxygen toxicity, caused from the harmful effects of breathing molecular oxygen at elevated partial pressures. Hyperoxia differs from hypoxia in that hyperoxia refers to a state in which oxygen supply is too much, whereas hypoxia refers to the state in which oxygen supply is insufficient.

Oxygen supplementation is common in the treatment of hypoxemia, an abnormally low level of oxygen in the blood. Hypoxemia can further cause tissue hypoxia as blood is not supplying sufficient oxygen to the rest of the body's tissues and organs, resulting in the need for further supplementation of oxygen. It is estimated that the annual need for supplemental oxygen is around 800,000 individuals with a cost of 1.8 billion dollars.[2]

In the environment, it refers to excess oxygen in a body of water or other habitat.

Signs and symptoms

Associated with hyperoxia is an increased level of reactive oxygen species (ROS), which are chemically reactive molecules containing oxygen. These oxygen containing molecules can cause damage to lipids, proteins, and nucleic acids by reacting to surrounding biological tissues. The human body has naturally occurring antioxidants to combat reactive molecules, but the protective antioxidant defenses can become overrun with reactive oxygen species leading to oxidation of the tissues and organs.[1]

The symptoms produced from breathing high concentrations of oxygen for long periods of time have been studied in a variety of animals, such as frogs, turtles, pigeons, mice, rats, guinea pigs, cats, dogs and monkeys. The majority of these studies reported the occurrence of irritation, congestion and edema of the lungs, and even death following prolonged exposures.[3]

Oxygen Toxicity

The supplementation of oxygen can lead to oxygen toxicity, also known as oxygen toxicity syndrome, oxygen intoxication, and oxygen poisoning. There are two main types of oxygen toxicity, central nervous system toxicity (CNS) and pulmonary and ocular toxicity. [4]

Temporary exposure to high partial pressures of oxygen at greater than atmospheric pressure can lead to central nervous system toxicity (CNS). An early but serious sign of CNS oxygen toxicity is a grand-mal seizure, also known as a generalized tonic-clonic seizure. This type of seizure consists of a loss of consciousness and violent muscle contractions. Signs and symptoms of oxygen toxicity are usually prevalent, but there are no standard warning signs that a seizure is about to ensue. The convulsion caused by oxygen toxicity does not lead to hypoxia, a side effect common to most seizures, because the body has an excess amount of oxygen when the convulsion begins. The seizures can lead to drowning, however, if the convulsion begins with the diver still in the water. [4]

Prolonged exposure to higher oxygen levels at atmospheric pressure can lead to pulmonary and ocular toxicity. Symptoms of oxygen toxicity may include disorientation, respiratory problems, as well as myopia. Prolonged exposure to higher than normal partial pressures of oxygen can result in oxidative damage to cell membranes. Signs of pulmonary (lung) oxygen toxicity begin with slight irritation in the trachea (throat). A mild cough usually ensues, followed by greater irritation and a worse cough until breathing becomes quite painful and the cough becomes uncontrollable. If supplementation of oxygen is continued, the individual will notice tightness in the chest, difficulty breathing, shortness of breath, and if exposure is continued long enough, the result can be fatal due to lack of oxygen.[4]


Oxygen that is supplied at greater than atmospheric pressure has been known to damage plants, animals, and aerobic bacteria such as Escherichia coli. Some studies have shown that even breathing oxygen at 21% has some damaging effects. The damaging effects vary depending on the specimen used, its age, physiological state and diet.

The supplementation of oxygen has been a common procedure of prehospital treatment for many years. Guidelines regarding supplementation of oxygen caution its use with chronic obstructive pulmonary disease (COPD). These guidelines stress the use of 28% oxygen masks and caution the dangers of hyperoxia. Long-term use of supplemental oxygen improves survival in patients with COPD, but can lead to a state of hyperoxia. [5]

An additional cause of hyperoxia is related to scuba diving. Scuba divers breath in a mixture of gasses composed of nitrogen and oxygen, a mixture also known as nitrox. Breathing nitrox can lead to hyperoxia due to the high partial pressure of oxygen.


Oxygen supplementation is used to decrease tissue hypoxia and to relieve arterial hypoxemia. High concentrations of oxygen are often used in patients with chronic obstructive pulmonary disease (COPD) or acute lung injury (ALI). Supplementing oxygen is known to cause tissue damage, with toxicity increasing with the increase of oxygen concentrations and exposure pressures. Unfortunately, the supplementation of oxygen is necessary if an individual is not able to retrieve enough oxygen on their own. To decrease the chances of hyperoxia, it is recommended to use the lowest concentration of oxygen required by an individual. As of today, there are no known alternatives to the supplementation of oxygen.[6]

See also

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  1. 1.0 1.1 Mach, William J.; Thimmesch, Amanda R.; Pierce, J. Thomas; Pierce, Janet D. "Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung". Nursing Research and Practice 2011: 1–7. doi:10.1155/2011/260482. 
  2. Kim, V; Benditt, JO; Wise, RA; Sharafkhaneh, A (May 1, 2008). "Oxygen therapy in chronic obstructive pulmonary disease.". Proceedings of the American Thoracic Society 5 (4): 513–8. PMC 2645328. PMID 18453364. doi:10.1513/pats.200708-124et. Retrieved October 27, 2014. 
  3. COMROE, JULIUS H. (7 July 1945). "OXYGEN TOXICITY". Journal of the American Medical Association 128 (10): 710. doi:10.1001/jama.1945.02860270012004. 
  4. 4.0 4.1 4.2 Sawatzky, David. "Oxygen Toxicity Signs and Symptoms". Retrieved 12 November 2014. 
  5. New, A (1 February 2006). "Oxygen: kill or cure? Prehospital hyperoxia in the COPD patient". Emergency Medicine Journal 23 (2): 144–146. doi:10.1136/emj.2005.027458. 
  6. Jenkinson, SG (November 1993). "Oxygen toxicity.". New horizons (Baltimore, Md.) 1 (4): 504–11. PMID 8087571.