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Hyperphosphatemia

Hyperphosphatemia
File:Phosphate Group.PNG
Phosphate group chemical structure
Classification and external resources
ICD-9 275.3
DiseasesDB 20722
eMedicine med/1097
NCI Hyperphosphatemia
Patient UK Hyperphosphatemia
MeSH D054559

Hyperphosphatemia is an electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood.[1] Often, calcium levels are lowered (hypocalcemia) due to precipitation of phosphate with the calcium in tissues. Average phosphorus levels should be between 0.81 mmol/L and 1.45 mmol/L.

Signs and symptoms

Signs and symptoms include ectopic calcification, secondary hyperparathyroidism, and renal osteodystrophy.

Causes

Causes of hyperphosphatemia[2]
Impaired renal phosphate excretion
Massive extracellular fluid phosphate loads

Hypoparathyroidism: In this situation, there are low levels of Parathyroid hormone (PTH). PTH normally inhibits reabsorption of phosphate by the kidney. Therefore, without enough PTH there is more reabsorption of the phosphate leading to a high phosphate level in the blood.

Chronic renal failure: When the kidneys are not working well, there will be increased phosphate retention.

Drugs: hyperphosphatemia can also be caused by taking oral sodium phosphate solutions prescribed for bowel preparation for colonoscopy in children.

Treatment

High phosphate levels can be avoided with phosphate binders and dietary restriction of phosphate.

See also

References

  1. "hyperphosphatemia" at Dorland's Medical Dictionary
  2. Longo et al., Harrison's Principles of Internal Medicine, 18th ed., p.3089