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Open Access Articles- Top Results for Hypocretin (orexin) receptor 1

Hypocretin (orexin) receptor 1

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Identifiers
SymbolsHCRTR1 ; OX1R
External IDsOMIM602392 MGI2385650 HomoloGene37492 IUPHAR: 321 ChEMBL: 5113 GeneCards: HCRTR1 Gene
RNA expression pattern
File:PBB GE HCRTR1 207619 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez3061230777
EnsemblENSG00000121764ENSMUSG00000028778
UniProtO43613P58307
RefSeq (mRNA)NM_001525NM_001163027
RefSeq (protein)NP_001516NP_001156499
Location (UCSC)Chr 1:
31.62 – 31.63 Mb
Chr 4:
130.13 – 130.14 Mb
PubMed search[1][2]

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1, is a protein that in humans is encoded by the HCRTR1 gene.[1]

Function

The orexin 1 receptor (OX1), is a G-protein coupled receptor expressed in the hypothalamus and involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.[1]

Ligands

Agonists

Antagonists

Further information: Orexin antagonist

See also

References

External links

  • "Orexin Receptors: OX1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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